Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Corneal edema
Eyelid twitching
Keratopathy
Miosis
(1993): Roberts CW, J Cataract Refract Surg 19(6), 731
Ocular burning
Ocular stinging
Ophthalmitis
CARBAMAZEPINE
Trade names: Apo-Carbamazepine; Atreol; Carbatrol; Epitol
(Teva); Foxsalepsin; Kodapan; Lexin; Mazepine; Sirtal; Tegretol
(Novartis); Tegretol XR; Teril; Timonil
Indications: Epilepsy, pain or trigeminal neuralgia
Category: Anticonvulsant; Antipsychotic; Mood stabilizer
Half-life: 18–55 hours
Clinically important, potentially hazardous interactions
with: acetylcysteine, adenosine, aprepitant, aripiprazole,
buprenorphine, caffeine, charcoal, clarithromycin, clobazam,
clorazepate, clozapine, darunavir, dasatinib, delavirdine,
dexamethasone, diltiazem, doxacurium, erythromycin, felodipine,
fosamprenavir, imatinib, influenza vaccines, lapatinib,
levetiracetam, lopinavir, methylprednisolone, midazolam,
nelfinavir, prednisolone, propoxyphene, ritonavir, solifenacin, St
John’s wort, telithromycin, temsirolimus, terbinafine,
troleandomycin, verapamil, voriconazole
Reactions
Skin
Acne keloid
(1990): Grunwald MH+, Int J Dermatol 29, 559
Acute generalized exanthematous pustulosis (AGEP)
(1999): Lachgar T, Allerg Immunol (Paris) (French) 31, 151
(1999): Poster Exhibit #163, AAD Meeting, March 1999
(Reported by ED and WB Shelley)
(1996): Wolkenstein P+, Contact Dermatitis 35, 234
(1995): Moreau A+, Int J Dermatol 34, 263 (passim)
(1991): Roujeau J-C+, Arch Dermatol 127, 1333
Adverse effects (sic)
(2003): Matthews R+, Br Dent J 194(3), 121
Allergic reactions (sic)
(1999): Pasmans SG+, Allergy 54, 649
(1995): Tijhuis GJ+, Ned Tijdschr Geneeskd (Dutch) 139, 2265
(42 cases)
(1993): Beran RG, Epilepsia 34, 163
(1992): Dzianott A+, Wiad Lek (Polish) 45, 465
(1985): Moore NC+, Am J Psychiatry 142, 974
Angioedema (