Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

CAPSICUM
Scientific names: Capsicum annuum; Capsicum baccatum;
Capsicum chinense; Capsicum frutescens; Capsicum pubscens
Family: Solanaceae
Trade and other common names: African chili; Bell pepper;
Bird pepper; Capsaicin; Capsicool; Capsin; Capzasin-P; Cayenne;
Cayenne Pepper; Chili; Dolorac; Goat’s pod; Ici Fructus;
Jalapeno; Louisiana long pepper; No Pain-HP; Oleoresin; Pain
Doctor (with methyl-salicylate and menthol); Pain-X; Paprika;
Pimento; R-Gel; Zanzibar pepper; Zostrix
Category: Rubefacient
Purported indications and other uses: nausea, neuropathic
pain, osteoarthritis, fibromyalgia, anticarcinogen, rheumatoid
arthritis, diabetic neuropathy, postherpetic neuralgia (shingles),
psoriasis, pruritus, vitiligo, dyspepsia, flatulence, ulcers, stomach
cramps, hypertension, improved circulation, weight-loss.
Half-life: N/A
Clinically important, potentially hazardous interactions
with: ACE inhibitors, antiplatelet drugs, aspirin, disulfiram,
heparin, latex, salicylic acid, theophylline, warfarin
Note: Pepper spray or gas contains 5% oleoresin capsicum (OC). It
is used by police and in personal defense sprays
Reactions
Skin
Acute febrile neutrophilic dermatosis (Sweet’s syndrome)
(1993): Greer JM+, Cutis 51(2), 112
Adverse effects (sic)
(2001): Keitel W+, Arzneimittelforschung 51(11), 896 (mild)
(2001): Stam C+, Br Homeopath J 90(1), 21 (11%)
(1991): Govindarajan VS+, Crit Rev Food Sci Nutr 29(6), 435
Allergic reactions (sic)
(2002): Groenewoud GC+, Clin Exp Allergy 32(3), 434
(1996): Sastre J+, Allergy 51(2), 117
Bullous dermatitis
(1993): Greer JM+, Cutis 51(2), 112
Burning
(2003): Fett DD, Cutis 72(1), 21
(1998): Busker RW+, Am J Forensic Med Pathol 19(4), 309
(spray)
(1990): Chan OY+, J Soc Occup Med 40(3), 111
(1987): Jones LA+, J Toxicol Clin Toxicol 25(6), 483
Dermatitis
(1996): Kanerva L+, Contact Dermatitis 35(3), 157
(1995): Williams SR+, Ann Emerg Med 25(5), 713
(1989): Burnett JW, Cutis 43(6), 534
Diaphoresis
(1985): Locock, Can Pharm J 118, 517
Erosions
(2000): Zollman TM+, Ophthalmology 107(12), 2186 (21%)
(spray)
Erythema
(1996): Watson WA+, Ann Pharmacother 30(7), 733
(1993): Greer JM+, Cutis 51(2), 112
(1987): Jones LA+, J Toxicol Clin Toxicol 25(6), 483
Erythema multiforme
(1995): Raccagni AA+, Contact Dermatitis 33(5), 353
Inflammation
(1998): Busker RW+, Am J Forensic Med Pathol 19(4), 309
(spray)
Irritation
(2001): Babakhanian RV+, Sud Med Ekspert 44(1), 9 (spray)
Pustules
CAPSICUM 87
(1993): Greer JM+, Cutis 51(2), 112
Sensitization
(1997): Gallo R+, Contact Dermatitis 37(1), 36
Stinging
(2003): Fett DD, Cutis 72(1), 21
Toxicoderma
(1985): Rogov VD, Vestn Dermatol Venerol comp(5), 53
Urticaria
(2003): Feldman H+, Am J Emerg Med 21(2), 159
(1997): Foti C+, Contact Dermatitis 37(3), 135
Mucosal
Gingivitis
(1991): Serio FG+, JPeriodontol62(6), 390
Mucosal bleeding
(1987): Myers BM+, Am J Gastroenterol 82(3), 211
Eyes
Conjunctivitis
(2003): Holopainen JM+, Toxicol Appl Pharmacol 186(3), 155
(spray)
(1996): Lee RJ+, J Am Optom Assoc 67(9), 548 (spray)
(1995): Steffee CH+, Am J Forensic Med Pathol 16(3), 185 (spray)
Epiphora
(1996): Lee RJ+, J Am Optom Assoc 67(9), 548 (spray)
Ocular burning
(1996): Watson WA+, Ann Pharmacother 30(7), 733 (spray)
Rhinoconjunctivitis
(1998): Vega de la Osada F+, Med Clin (Barc) 111(7), 263
Other
Application-site burning
(1992): Tandan R+, Diabetes Care 15(1), 8
Cough
(1991): Blanc P+, Chest 99(1), 27
Death
(2001): Olajos EJ+, J Appl Toxicol 21(5), 355 (spray)
(1998): Pollanen MS+, CMAJ 158(12), 1603 (spray)
(1995): Steffee CH+, Am J Forensic Med Pathol 16(3), 185 (spray)
(1989): Mack RB, NCMedJ50(11), 627 (spray)
Fibrosis
(1988): Escobar CH, Rev ADM 45(6), 369
Hypersensitivity
(2002): Groenewoud GC+, Clin Exp Allergy 32(3), 434
(1998): Busker RW+, Am J Forensic Med Pathol 19(4), 309
(spray)
Pain
(2000): Zollman TM+, Ophthalmology 107(12), 2186 (spray)
(1995): Steffee CH+, Am J Forensic Med Pathol 16(3), 185 (spray)
(1992): Landau O+, JAMA 268(13), 1686
(1991): Marabini S+, Eur Arch Otorhinolaryngol 248(4), 191
(1987): Jones LA+, J Toxicol Clin Toxicol 25(6), 483