Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Myalgia/Myositis/Myopathy/Myotoxicity (6%) (2003): Iskandar SB+, Tenn Med 96(10), 471 (1999): Peloso PM+, JAMA 282, 1817 Rhabdomyolysis (2004): Bobe F+, Scand J Prim Health Care 22(3), 191 (1999): David D+, J Clin Psychopharmacol 19(2), 185 Serum sickness (2004): Hack S, J Child Adolesc Psychopharmacol 14(3), 478 (2004): Ornetti P+, Joint Bone Spine 71(6), 583 (2002): Wooltorton E, CMAJ 166(1), 68 (2001): Davis JS+, Med J Aust 174, 479 (2000): McCollom RA+, Ann Pharmacother 34, 471 (1999): Peloso PM+, JAMA 282, 1817 (1999): Tripathi A+, Ann Allergy Asthma Immunol 83, 165 (1999): Yolles JC+, Ann Pharmacother 33, 931 BUSPIRONE Trade names: Ansail; Apo-Buspirone; Bespar; Biron; Busirone; BuSpar (Bristol-Myers Squibb); Bustab; Kallmiren; Narol; Neurosine; Nu-Buspirone Indications: Anxiety Category: Anxiolytic; Serotonin antagonist Half-life: 2–3 hours Clinically important, potentially hazardous interactions with: grapefruit juice, nefazodone, ritonavir, St John’s wort Reactions Skin Acne (

82 BUSULFAN Other Anhidrosis Death (2004): Nakamae H+, Chemotherapy 50(4), 178 Gynecomastia (

Myalgia/Myositis/Myopathy/Myotoxicity (6%)<br />

(2003): Isk<strong>and</strong>ar SB+, Tenn Med 96(10), 471<br />

(1999): Peloso PM+, JAMA 282, 1817<br />

Rhabdomyolysis<br />

(2004): Bobe F+, Sc<strong>and</strong> J Prim Health Care 22(3), 191<br />

(1999): David D+, J Clin Psychopharmacol 19(2), 185<br />

Serum sickness<br />

(2004): Hack S, J Child Adolesc Psychopharmacol 14(3), 478<br />

(2004): Ornetti P+, Joint Bone Spine 71(6), 583<br />

(2002): Wooltorton E, CMAJ 166(1), 68<br />

(2001): Davis JS+, Med J Aust 174, 479<br />

(2000): McCollom RA+, Ann Pharmacother 34, 471<br />

(1999): Peloso PM+, JAMA 282, 1817<br />

(1999): Tripathi A+, Ann Allergy Asthma Immunol 83, 165<br />

(1999): Yolles JC+, Ann Pharmacother 33, 931<br />

BUSPIRONE<br />

Trade names: Ansail; Apo-Buspirone; Bespar; Biron; Busirone;<br />

BuSpar (Bristol-Myers Squibb); Bustab; Kallmiren; Narol;<br />

Neurosine; Nu-Buspirone<br />

Indications: Anxiety<br />

Category: Anxiolytic; Serotonin antagonist<br />

Half-life: 2–3 hours<br />

Clinically important, potentially hazardous interactions<br />

with: grapefruit juice, nefazodone, ritonavir, St John’s wort<br />

Reactions<br />

Skin<br />

Acne (

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