Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Erythema multiforme (

80 BUPRENORPHINE Hepatotoxicity (2006): Prescrire Int 15(82), 64 (2004): Herve S+, Eur J Gastroenterol 16(10), 1033 (5 cases) (2001): Wisniewski B+, Gastroenterol Clin Biol 25(3), 328 (2000): Petry NM+, Am J Addict 9(3), 265 Injection-site erythema (2006): Likar R+, Clin Ther 28(6), 943 (12.1%) Injection-site exanthems (2006): Likar R+, Clin Ther 28(6), 943 (8.8%) Injection-site pain (1993): Torres LM+, Rev Esp Anestesiol Reanim 40(4), 181 Injection-site pruritus (2006): Likar R+, Clin Ther 28(6), 943 Myalgia/Myositis/Myopathy/Myotoxicity (2004): Ray R+, Pharmacoepidemiol Drug Saf 13(9), 615 (39.5%) Neurotoxicity (2006): Seet RC+, Ann Emerg Med 47(4), 396 Rhabdomyolysis (2006): Seet RC+, Ann Emerg Med 47(4), 396 *Note: Suboxone contains naloxone BUPROPION Trade names: Wellbutrin (GSK); Zyban (GSK) Indications: Depression, aid to smoking cessation Category: Antidepressant; Dopamine reuptake inhibitor Half-life: 14 hours Clinically important, potentially hazardous interactions with: cyclosporine, erythromycin, escitalopram, isocarboxazid, methylphenidate, phenelzine, ritonavir, tranylcypromine, trimipramine Reactions Skin Acne (1–10%) Angioedema Diaphoresis (5%) (2001): Pederson KJ+, Can J Cardiol 17(5), 599 (1984): Feighner JP+, Am J Psychiatry 141(4), 525 (1983): Feighner JP, J Clin Psychiatry 44, 49 (1981): Halaris AE+, Psychopharmacol Bull 17, 140 Edema (>1%) (1999): Peloso PM+, JAMA 282, 1817 Erythema multiforme (2002): Drago F+, Arch Intern Med 162(7), 843 (2001): Carrillo-Jimenez R+, Arch Intern Med 161(12), 1556 (2001): Lineberry TW+, Mayo Clin Proc 76, 664 Exanthems (

Erythema multiforme (

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