Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

BROMFENAC
Trade name: Xibrom (ISTA Pharma)
Indications: Postoperative ophthalmic inflammation
Category: Non-steroidal anti-inflammatory
Half-life: N/A
Clinically important, potentially hazardous interactions
with: NSAIDs
Reactions
Eyes
Conjunctival hyperemia
Corneal melting
(2006): Asai T+, Cornea 25(2), 224 (3 cases)
Iritis
Ocular burning
Ocular erythema
Ocular pain
Ocular stinging
Note: Bromfenac contains sodium sulfite, which may cause
hypersensitivity in sensitive individuals
BROMOCRIPTINE
Trade names: Apo-Bromocriptine; Bromed; Cryocriptina;
Kripton; Parilac; Parlodel (Novartis); Pravidel; Serocryptin
Indications: Amenorrhea, parkinsonism, infertility
Category: Dopamine receptor agonist
Half-life: initial: 6–8 hours; terminal: 50 hours
Clinically important, potentially hazardous interactions
with: erythromycin, pseudoephedrine, sympathomimetics
Reactions
Skin
Diaphoresis
(1998): Nakasu Y+, Neurol Med Chir (Tokyo) 38(10), 669
Exanthems
Livedo reticularis
(1985): Hoehn MMM+, Neurology 35, 199
Morphea
(1989): Leshin B+, Int J Dermatol 28, 177
Nodular eruption
Purpura
Rash (sic)
Raynaud’s phenomenon (1–10%)
(1996): Zenone T+, Rev Med Interne 17(11), 948
(1987): Quagliarello J+, Fertil Steril 48(5), 877
Scleroderma
(1989): Leshin B+, Int J Dermatol 28, 177
(1983): Dupont E+, Neurology 33, 670
Urticaria
Vasculitis
Mucosal
Xerostomia (4–10%)
(1985): Hoehn MMM+, Neurology 35, 199
(1982): Gauthier G+, Eur Neurol 21, 217
Hair
Hair – alopecia
(1993): Fabre N+, Clin Neuropharmacol 16, 266
(1980): Blum I+, NEnglJMed303, 1418
Eyes
Visual hallucinations
(1980): Goodkin DA, NEnglJMed302(26), 1479
Other
Anaphylactoid reactions/Anaphylaxis
(1980): Parkes S, NEnglJMed302, 750
Erythromelalgia
(1983): Dupont E+, Neurology 33, 670
(1981): Eisler T+, Neurology 31, 1368
Pseudolymphoma
(2000): Wiesli P+, Clin Endocrinol (Oxford) 53(5), 656
BROMPHENIRAMINE
Trade names: Bromfed (Muro); Bromine; Brommine;
Bromphen; Dimegan; Dimetane; Ilvin; Kinmedon; Nasahist; ND-
Stat; Neo-Meton; Rondec (Biovail)
Indications: Allergic rhinitis, urticaria
Category: Histamine H1 receptor antagonist
Half-life: 12–48 hours
Clinically important, potentially hazardous interactions
with: aprobarbital, butabarbital, chloral hydrate, ethchlorvynol,
mephobarbital, pentobarbital, phenobarbital, phenothiazines,
primidone, secobarbital, zolpidem
Reactions
Skin
Angioedema (