Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

BLOODROOT
Scientific name: Sanguinaria canadensis
Family: Papaveraceae
Trade and other common names: Coon Root; Indian Plant;
Indian Red Paint; Red Puccoon; Red Root; Snakebite; Sweet
Slumber; Tetterwort; Viadent
Category: Anti-inflammatory
Purported indications and other uses: Oral: emetic,
cathartic, expectorant. Topical: debriding agent, bronchitis,
asthma, croup, laryngitis, pharyngitis, scabies, eczema, athlete’s
foot, nasal polyps, rheumatism, fever, anemia
Half-life: N/A
Reactions
Skin
Dermatitis
(1998): Brinker F, Contraindications and Drug Interactions Eclectic
Medical Publications
Irritation (sic)
Keratoses
(2000): Eversole LR+, Oral Surg Oral Med Oral Pathol Oral Radiol
Endod 89(4), 455
Mucosal
Leukoplakia
(2001): Allen CL+, Gen Dent 49(6), 608
(2000): Eversole LR+, Oral Surg Oral Med Oral Pathol Oral Radiol
Endod 89(4), 455
BLUE COHOSH
Scientific name: Caulophyllum thalictroides
Family: Berberidaceae
Trade and other common names: Beechdrops; Blue ginseng;
Blueberry root; Papoose root; Squawroot; Yellow ginseng
Category: Diuretic; Oxytocic
Purported indications and other uses: Rheumatism, dropsy,
epilepsy, hysteria, uterine inflammation, thrush, menopause,
headache, sexual debility, aphthous stomatitis, laxative, colic, sore
throat, hiccups
Half-life: N/A
Clinically important, potentially hazardous interactions
with: cardioactive drugs
Reactions
Skin
Allergic reactions (sic)
Diaphoresis
(2002): Rao RB+, Vet Hum Toxicol 44(4), 221
Mucosal
Mucosal irritation
Other
Myalgia/Myositis/Myopathy/Myotoxicity
(2002): Rao RB+, Vet Hum Toxicol 44(4), 221
Note: Cohosh is from the Algonquin word ‘rough’, referring to the
appearance of the roots. It is a toxic herb and should not be confused
with the safer, unrelated herb, Black Cohosh
BORTEZOMIB
Synonyms: PS-341; LDP-341
Trade name: Velcade (Millennium)
Indications: Multiple myeloma
Category: Proteasome inhibitor
Half-life: 9–15 hours
Clinically important, potentially hazardous interactions
with: None
Reactions
BORTEZOMIB 73
Skin
Acute febrile neutrophilic dermatosis (Sweet’s syndrome)
(2005): Knoops L+, Br J Haematol 131(2), 142
(2005): Van Regenmortel N+, Haematologica 90(12
Suppl), ECR43
Edema (25%)
Erythema
(2006): Wu KL+, JAmAcadDermatol55(5), 897
Folliculitis
(2005): Pour L+, Haematologica 90(12 Suppl), ECR44
Herpes zoster (11%)
(2005): Wu KL+, Clin Lymphoma Myeloma 6(2), 96
(2003): Richardson PG, Clin Adv Hematol Oncol A(10), 596
Pruritus (11%)
(2002): Aghajanian C+, Clin Cancer Res 8(8), 2505
Purpura
(2005): Agterof MJ+, NEnglJMed352(24), 2534
Rash (sic) (21%)
(2005): Richardson PG+, NEnglJMed352(24), 2487
(2002): Aghajanian C+, Clin Cancer Res 8(8), 2505
Ulcerations
(2006): Wu KL+, JAmAcadDermatol55(5), 897
Vasculitis
(2006): Gerecitano J+, Br J Haematol 134(4), 391
(2006): Min CK+, Eur J Haematol 76(3), 265
(2005): Agterof MJ+, NEnglJMed352(24), 2534
Mucosal
Stomatitis
Other
Abdominal pain
(2005): Richardson PG+, NEnglJMed352(24), 2487
Anaphylactoid reactions/Anaphylaxis
Cough (17%)
(2005): Richardson PG+, NEnglJMed352(24), 2487
Death
(2006): Bang SM+, Int J Hematol 83(4), 309 (6%)
(2005): Goy A+, J Clin Oncol 23(4), 667 (3 cases)
Fever (36%)
(2006): Wu KL+, JAmAcadDermatol55(5), 897
(2005): Dimopoulos MA+, Haematologica 90(12), 1655
(2002): Aghajanian C+, Clin Cancer Res 8(8), 2505
Hypersensitivity
Infections
(2006): Kroger N+, Exp Hematol 34(6), 770
Injection-site irritation (5%)
Myalgia/Myositis/Myopathy/Myotoxicity (14%)
Neurotoxicity
(2006): Prescrire Int 15(83), 98
(2006): Bang SM+, Int J Hematol 83(4), 309
(2006): Gupta S+, Haematologica 91(7), 1001
(2006): Kane RC+, Clin Cancer Res 12(10), 2955
(2006): Kroger N+, Exp Hematol 34(6), 770 (17%)
(2006): Richardson PG+, J Clin Oncol 24(19), 3113