Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

BLEOMYCIN
Synonyms: bleo; BLM
Trade names: Blenoxane (Mead Johnson); Bleo; Bleocin;
Bleomycine; Bleomycinum; BLM
Indications: Melanomas, sarcomas, lymphomas, testicular
carcinoma
Category: Antibiotic, anthracycline
Half-life: 1.3–9 hours
Clinically important, potentially hazardous interactions
with: aldesleukin
Reactions
Skin
Acral erythema
(2005): Tsuboi H+, JDermatol32(11), 921
(1982): Burgdorf WHC+, AnnInternMed97, 61
Acral necrosis
(1998): Reiser M+, Eur J Clin Microbiol Infect Dis 17, 58
(1997): Hladunewich M+, J Rheumatol 24, 2371
Acral sclerosis
(1984): Snauwaert J+, Dermatologica 169, 172
Allergic reactions (sic)
(1998): Mullai N+, J Clin Oncol 16, 1625
(1998): Yeo W+, J Clin Oncol 16, 1626
Angioedema
(1984): Khansur T+, Arch Intern Med 144, 2267
Bullous dermatitis (1–5%)
Calcification
(1983): Bork K+, Hautarzt (German) 34, 10
Dermatitis
Eccrine squamous syringometaplasia
(2005): Tsuboi H+, JDermatol32(11), 921
Erythema
(2005): Mseddi M+, Rev Med Liege 60(10), 772 (flagellate)
(2003): Nayak N+, Clin Exp Dermatol 28(1), 105
(2001): Robinson JB+, Gynecol Oncol 82(3), 550
(1980): Lincke-Plewig H, Hautarzt (German) 31, 616
Erythema gyratum
(1997): Polsky D+, New York, American Academy of
Dermatology Meeting (SF), (gross and microscopic)
Exanthems
(1993): Haerslev T+, Cutis 52, 45 (linear and symmetrical)
(1980): Lincke-Plewig H, Hautarzt (German) 31, 616
Fixed eruption
(1987): Lindae ML+, Arch Dermatol 123(3), 395
Flagellate erythema / pigmentation
(2007): Chen YB+, J Clin Oncol 25(7), 898
(2006): Kumar R+, Indian Pediatr 43(1), 74
(2006): Yamamoto T+, Int J Dermatol 45(5), 627
(2005): Mikhail M+, J Drugs Dermatol 4(1), 81
(2005): Mseddi M+, Rev Med Liege 60(10), 772
(2003): Abess A+, Arch Dermatol 139(3), 337
(2003): Nayak N+, Clin Exp Dermatol 28(1), 105
(2002): Gupta LK+, Indian J Dermatol Venereol Leprol 68(3), 158
(2000): Spedini P+, Haematologica 85(8), 870
(1999): Rubeiz NG+, Int J Dermatol 38(2), 140
(1998): Yamamoto T+, Dermatology 197(4), 399
(1994): Mowad CM+, Br J Dermatol 131(5), 700
(1994): Templeton SF+, Arch Dermatol 130(5), 577
(1994): Zaki I+, Clin Exp Dermatol 19(4), 366
(1993): Tsuji T+, JAmAcadDermatol28(3), 503
(1992): Albig J+, Hautarzt 43(6), 376
(1992): Jolin Garijo L+, An Med Interna 9(10), 520
(1991): Duhra P+, Clin Exp Dermatol 16(3), 216
(1990): Cortina P+, Dermatologica 180(2), 106
BLEOMYCIN 71
(1990): Miori L+, Am J Dermatopathol 12(6), 598
(1990): Miori L+, Dermatologica 181(3), 238
(1990): Vicente MA+, Med Cutan Ibero Lat Am 18(2), 148
(1990): Wright AL+, Dermatologica 180(4), 255
(1989): Vignini M+, Clin Exp Dermatol 14(3), 261
(1988): Lazar AP+, Cutis 42(5), 397
(1988): Massone L+, G Ital Dermatol Venereol 123(5), 225
(1987): Lindae ML+, Arch DermatolPG 123(3), 395
(1987): Rademaker M+, Clin Exp Dermatol 12(6), 457
(1986): Polla BS+, JAmAcadDermatol14(4), 690
(1985): Fernandez-Obregon AC+, JAmAcadDermatol
13(3), 464
(1984): Schuler G+, Hautarzt - Der 35(7), 383
Hand–foot syndrome
(2005): Mikhail M+, JDrugsDermatol4(1), 81
Hyperkeratosis (palms and soles)
Ichthyosis
Intertrigo
Linear streaking
(1989): Vignini M+, Clin Exp Dermatol 14, 261
(1988): Lazar A+, Cutis 42, 397
(1987): Rademaker M+, Clin Exp Dermatol 12, 457
Neutrophilic eccrine hidradenitis
(1998): Wenzel FG+, JAmAcadDermatol38(1), 1
(1988): Scallan PJ+, Cancer 62, 2532
Nodular eruption
(2005): Mikhail M+, JDrugsDermatol4, 81
Palmar nodules
(1993): Haerslev T+, Cutis 52, 45
Palmar–plantar erythema
(1990): Pagliuca A+, Postgrad Med J 66, 242
Papulo-nodular lesions
(1997): Polsky D+, New York, American Academy of
Dermatology Meeting (SF), (gross and microscopic)
Photo-recall
(1993): Stelzer KJ+, Cancer 71, 1322
Pigmentation (~50%)
(2003): Abess A+, Arch Dermatol 139(3), 337
(2003): Nayak N+, Clin Exp Dermatol 28(1), 105
(2002): vonHilsheimer GE+, JAmAcadDermatol46(4), 642
(2001): Mutafoglu-Uysal K+, Turk J Pediatr 43(2), 172
(1999): Susser WS+, JAmAcadDermatol40(3), 367
(1998): Behrens S+, Hautarzt (German) 49, 725
(1993): Tsuji T+, JAmAcadDermatol28, 503 (in striae distensae)
(1992): Gallais V+, Ann Dermatol Venereol (French) 119, 471
(1990): Wright AL+, Dermatologica 181, 255 (reticulate)
(1988): Massone L+, G Ital Dermatol Venereol (Italian) 123, 225
(striae)
(1986): Guillet G+, Arch Dermatol 122, 381 (in stripes)
(1985): Polla L+, Ann Dermatol Venereol (French) 112, 821
(1984): Schuler G+, Hautarzt (German) 35, 383 (linear)
(1983): Bork K+, Hautarzt (German) 34, 10
(1982): Kukla LJ+, Cancer 50, 2283
(1981): Granstein RD+, JAmAcadDermatol5, 1 (brown-black)
(1981): Nixon DW+, Cutis 27, 181
Pruritus (>5%)
(2001): Robinson JB+, Gynecol Oncol 82(3), 550
(1995): Watanabe T+, Dermatology 190(3), 230
(1994): Templeton SF+, Arch Dermatol 130(5), 577 (generalized)
(1990): Caumes E+, Lancet 336, 1593
(1990): Cortina P+, Dermatologica 180(2), 106
(1985): Fernandez-Obregon AC+, JAmAcadDermatol
13(3), 464
Raynaud’s phenomenon (>10%)
(2001): Vanhooteghem O+, Pediatr Dermatol 18(3), 249
(1998): Reiser M+, Eur J Clin Microbiol Infect Dis 17, 58
(1997): Emmerich J, Presse Med (French) 26, 1580
(1997): Hladunewich M+, J Rheumatol 24, 2371
(1997): Sibilia J+, Presse Med (French) 26, 1564 (12.6%)