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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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(2002): Gruson LM+, Arch Pediatr Adolesc Med 156(11), 1091<br />

Other<br />

Tumors<br />

(1990): Young AR+, J Photochem Photobiol B 7(2), 231<br />

Note: Oil of bergamot possesses photosensitive <strong>and</strong> melanogenic<br />

properties because of the presence of furocoumarins, primarily<br />

bergapten (5-methoxypsoralen [5-MOP]). Its use is restricted or<br />

banned in many countries<br />

BETA-CAROTENE<br />

Trade names: B-Tene; Betavin; Carotaben; Lumitene; Max-<br />

Caro; Solatene (Merck); Solvin<br />

Indications: Photosensitivity reactions<br />

Category: Vitamin<br />

Half-life: N/A<br />

Clinically important, potentially hazardous interactions<br />

with: bexarotene<br />

Reactions<br />

Skin<br />

Carotenemia (>10%)<br />

(2000): Frieling UM+, Arch Dermatol 136, 179 (15.9%)<br />

Dermatitis<br />

(1992): Zürcher K <strong>and</strong> Krebs A, Cutaneous <strong>Drug</strong> Reactions<br />

Karger, 280<br />

Purpura (

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