02.06.2013 Views

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

64 BENZTROPINE<br />

BENZTROPINE<br />

Trade names: Akitan; Apo-Benzthioprine; Cogentin (Merck);<br />

Cogentine; Cogentinol; Phatropine; PMS-Benztropine<br />

Indications: Parkinsonism<br />

Category: Anticholinergic; Muscarinic antagonist<br />

Half-life: 6–48 hours<br />

Clinically important, potentially hazardous interactions<br />

with: anticholinergics, haloperidol<br />

Reactions<br />

Skin<br />

Exanthems<br />

Photosensitivity (1–10%)<br />

Pruritus<br />

Rash (sic) (10%)<br />

Mucosal<br />

Glossodynia<br />

Stomatodynia<br />

Tongue black<br />

(2000): Heymann WR, Cutis 66, 25<br />

Xerostomia (>10%)<br />

(2000): Heymann WR, Cutis 66, 25<br />

(1991): Goff DC+, J Clin Psychopharmacol 11(2), 106<br />

(1989): Gelenberg AJ+, J Clin Psychopharmacol 9, 180<br />

Other<br />

Death<br />

(2001): Lynch MJ+, Med Sci Law 41(2), 155<br />

Rhabdomyolysis<br />

(1984): Thase ME+, J Clin Psychopharmacol 4(1), 46 (with<br />

loxapine)<br />

BEPRIDIL<br />

Trade names: Bapadin; Bepricol; Cordium; Cruor; Vascor<br />

(Ortho-McNeil)<br />

Indications: Angina pectoris<br />

Category: Antiarrhythmic class IV; Calcium channel blocker<br />

Half-life: 24 hours<br />

Clinically important, potentially hazardous interactions<br />

with: amprenavir, atazanavir, ciprofloxacin, enoxacin, epirubicin,<br />

fosamprenavir, gatifloxacin, lomefloxacin, mistletoe,<br />

moxifloxacin, norfloxacin, ofloxacin, quinolones, ritonavir,<br />

sparfloxacin, tipranavir<br />

Reactions<br />

Skin<br />

Diaphoresis (

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!