Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

BENZALKONIUM
Synonyms: parasterol; drapolene; germitol; gesminol; rodalon;
ammonyx; benirol; enuclene
Trade names: Benza; Mycocide; Ony-Clear; Zephrex (Sanofi-
Aventis)
Indications: Antisepsis, Preoperative skin preparation, Wound
treatment, vaginal douch
Category: Antiseptic
Half-life: N/A
Clinically important, potentially hazardous interactions
with: None
Reactions
Skin
Allergic reactions (sic)
(1994): Cox NH, Contact Dermatitis 31(1), 50
(1991): Klein GF+, Contact Dermatitis 25(4), 269
Dermatitis
(2006): Haj-Younes L+, Contact Dermatitis 54(1), 69
(2001): Wong DA+, Australas J Dermatol 42(1), 33
(2000): Kanerva L+, Contact Dermatitis 42(6), 357
(2000): Park HJ+, Contact Dermatitis 42(5), 306
(1999): Diaz-Ramon L+, Contact Dermatitis 41(1), 53
(1997): Chiambaretta F+, JFrOphtalmol20(1), 8 (2 cases)
(1997): Krogsrud NE+, Contact Dermatitis 36(2), 112 (airborne)
(1996): Ortiz-Frutos FJ+, Contact Dermatitis 35(5), 302
(1996): Placucci F+, Contact Dermatitis 35(5), 306
(1993): Corazza M+, Contact Dermatitis 28(3), 195 (airborne)
(1993): Cusano F+, Contact Dermatitis 28(2), 127
(1993): Fuchs T+, Hautarzt 44(11), 699 (225 cases)
(1988): Trevisan G+, G Ital Dermatol Venereol 123(10), 513
Eyes
Ocular adverse effects (sic)
(1997): Chiambaretta F+, JFrOphtalmol20(1), 8 (2 cases)
Ocular allergy (sic)
(2003): Ventura MT+, Immunopharmacol Immunotoxicol
25(4), 529
Other
Anaphylactoid reactions/Anaphylaxis
(2004): Kim SH+, J Korean Med Sci 19(2), 289
Hypersensitivity
(1997): Chiambaretta F+, JFrOphtalmol20(1), 8 (2 cases)
BENZONATATE
Trade names: Beknol; Benzonal; Pebegal; Tesalon; Tessalon
(Forest); Tusehli
Indications: Symptomatic relief of cough
Category: Antitussive
Half-life: Duration: 3–8 hours
Clinically important, potentially hazardous interactions
with: None
Skin
Pruritus
Rash (sic) (1–10%)
Eyes
Ocular burning (1–10%)
Reactions
Other
Chills
Death
(1998): Crouch BI+, J Toxicol Clin Toxicol 36(7), 713 (2 cases)
(1986): Cohan JA+, Vet Hum Toxicol 28(6), 543
Hypersensitivity
Note: Benzonatate is related to tetracaine and other anesthetics of
the para-aminobenzoic acid class
BENZPHETAMINE
Trade names: Didrex (Pfizer); Inapetyl
Indications: Adjunct to diet plan to reduce weight
Category: Amphetamine
Half-life: N/A
Clinically important, potentially hazardous interactions
with: furazolidone, guanethidine, MAO inhibitors, SSRIs
Reactions
Skin
Allergic reactions (sic)
Diaphoresis
Erythema
Rash (sic)
Urticaria
Mucosal
Xerostomia
Hair
Hair – alopecia
Other
Gynecomastia
Hypersensitivity
Myalgia/Myositis/Myopathy/Myotoxicity
BENZTHIAZIDE
Trade names: Aquatag; Diurin; Exna; Fovane; Hydrex;
Marazide; Proaqua; Regulon
Indications: Hypertension
Category: Diuretic, thiazide
Half-life: N/A
Clinically important, potentially hazardous interactions
with: digoxin, lithium
Reactions
BENZTHIAZIDE 63
Skin
Allergic reactions (sic) (