Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

58 BACITRACIN
(1997): Dyck ED+, Allergy 52(8), 870
(1995): Knowles SR+, Int J Dermatol 34(8), 572
(1994): Fox KA, JEmergNurs20(4), 262
(1990): Eedy DJ+, Postgrad Med J 66(780), 858
(1990): Sprung J+, Anesth Analg 71(4), 430
(1987): Netland PA+, Neurosurgery 21(6), 927
(1986): Goh CL, Australas J Dermatol 27(3), 125
(1984): Schechter JF+, Arch Dermatol 120(7), 909
Injection-site pain
Nephrotoxicity (from intramuscular injections)
*Note: Bacitracin is supplied in many forms and vehicles:
Intramuscular; topical, ophthalmic, otic, aerosols, for irrigations.
Many Bacitracin ointments are combinations with Neomycin and
Polymyxin B.
BACLOFEN
Trade names: Alpha-Baclofen; Baclofen (Watson); Baclon;
Baclosal; Baklofen; Clofen; Dom-Baclofen; Gen-Baclofen; Lebic;
Lioresal (Medtronic); Nu-Baclo; Pacifen; PMS-Baclofen; Spinax
Indications: Spasticity resulting from multiple sclerosis
Category: GABA receptor agonist; Skeletal muscle relaxant
Half-life: 2.5–4 hours
Clinically important, potentially hazardous interactions
with: alcohol
Reactions
Skin
Allergic granulomatous angiitis
(2006): Murphy PM+, Anesth Analg 102(3), 848
Dermatitis
Diaphoresis
Exanthems
(1983): Lynde CW+, Ann Neurol 13, 216
Facial edema
Peripheral edema
(1993): Albright AL+, JAMA 270, 2475
Pruritus
(2005): Ben Smail D+, Arch Phys Med Rehabil 86(3), 494
(withdrawal)
Rash (sic) (1–10%)
Side effects (sic) (1–2%)
Toxicity (sic)
(1994): Aisen ML+, Arch Phys Med Rehabil 75(1), 109
Urticaria
Mucosal
Xerostomia (10%)
Cyst (3–10%)
Edema (generalized) (3–10%)
Facial edema (3–10%)
Genital edema (3–10%)
Hematomas (3–10%)
Herpes simplex (3–10%)
Herpes zoster
Peripheral edema (>10%)
Pruritus (3–10%)
(2002): Leonard PA+, Transplantation 74(12), 1697
Rash (sic) (3–10%)
(2002): Leonard PA+, Transplantation 74(12), 1697
Ulcerations (3–10%)
Vasculitis
Wound complications (sic) (>10%)
Mucosal
Gingival hyperplasia/hypertrophy (3–10%)
Stomatitis (3–10%)
Tongue edema
(2002): Leonard PA+, Transplantation 74(12), 1697
Ulcerative stomatitis