Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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(1997): Epstein ME+, JAmAcadDermatol37, 149 (passim) (1990): Adkinson NF, Am J Med 88 (Suppl 3C), 12S (1986): Brogden RN+, Drugs 18, 241 (1.8%) Purpura (1997): Epstein ME+, JAmAcadDermatol37, 149 (passim) (1990): Adkinson NF, Am J Med 88 (Suppl 3C), 12S (0.1%) Rash (sic) (1–10%) (1985): Newman TJ+, Rev Infect Dis 7, S648 Toxic epidermal necrolysis (1997): Epstein ME+, JAmAcadDermatol37, 149 (passim) (1992): McDonald BJ+, Ann Pharmacother 26, 34 Urticaria (1997): Epstein ME+, JAmAcadDermatol37, 149 (passim) (1993): de la Fuente-Prieto R+, Allergy 48, 634 (1991): Hantson P+, BMJ 302, 294 (1990): Adkinson NF, Am J Med 88 (Suppl 3C), 12S (0.2%) (1990): Soto Alvarez J+, Lancet 335, 1094 Mucosal Aphthous stomatitis (

58 BACITRACIN (1997): Dyck ED+, Allergy 52(8), 870 (1995): Knowles SR+, Int J Dermatol 34(8), 572 (1994): Fox KA, JEmergNurs20(4), 262 (1990): Eedy DJ+, Postgrad Med J 66(780), 858 (1990): Sprung J+, Anesth Analg 71(4), 430 (1987): Netland PA+, Neurosurgery 21(6), 927 (1986): Goh CL, Australas J Dermatol 27(3), 125 (1984): Schechter JF+, Arch Dermatol 120(7), 909 Injection-site pain Nephrotoxicity (from intramuscular injections) *Note: Bacitracin is supplied in many forms and vehicles: Intramuscular; topical, ophthalmic, otic, aerosols, for irrigations. Many Bacitracin ointments are combinations with Neomycin and Polymyxin B. BACLOFEN Trade names: Alpha-Baclofen; Baclofen (Watson); Baclon; Baclosal; Baklofen; Clofen; Dom-Baclofen; Gen-Baclofen; Lebic; Lioresal (Medtronic); Nu-Baclo; Pacifen; PMS-Baclofen; Spinax Indications: Spasticity resulting from multiple sclerosis Category: GABA receptor agonist; Skeletal muscle relaxant Half-life: 2.5–4 hours Clinically important, potentially hazardous interactions with: alcohol Reactions Skin Allergic granulomatous angiitis (2006): Murphy PM+, Anesth Analg 102(3), 848 Dermatitis Diaphoresis Exanthems (1983): Lynde CW+, Ann Neurol 13, 216 Facial edema Peripheral edema (1993): Albright AL+, JAMA 270, 2475 Pruritus (2005): Ben Smail D+, Arch Phys Med Rehabil 86(3), 494 (withdrawal) Rash (sic) (1–10%) Side effects (sic) (1–2%) Toxicity (sic) (1994): Aisen ML+, Arch Phys Med Rehabil 75(1), 109 Urticaria Mucosal Xerostomia (10%) Cyst (3–10%) Edema (generalized) (3–10%) Facial edema (3–10%) Genital edema (3–10%) Hematomas (3–10%) Herpes simplex (3–10%) Herpes zoster Peripheral edema (>10%) Pruritus (3–10%) (2002): Leonard PA+, Transplantation 74(12), 1697 Rash (sic) (3–10%) (2002): Leonard PA+, Transplantation 74(12), 1697 Ulcerations (3–10%) Vasculitis Wound complications (sic) (>10%) Mucosal Gingival hyperplasia/hypertrophy (3–10%) Stomatitis (3–10%) Tongue edema (2002): Leonard PA+, Transplantation 74(12), 1697 Ulcerative stomatitis

(1997): Epstein ME+, JAmAcadDermatol37, 149 (passim)<br />

(1990): Adkinson NF, Am J Med 88 (Suppl 3C), 12S<br />

(1986): Brogden RN+, <strong>Drug</strong>s 18, 241 (1.8%)<br />

Purpura<br />

(1997): Epstein ME+, JAmAcadDermatol37, 149 (passim)<br />

(1990): Adkinson NF, Am J Med 88 (Suppl 3C), 12S (0.1%)<br />

Rash (sic) (1–10%)<br />

(1985): Newman TJ+, Rev Infect Dis 7, S648<br />

Toxic epidermal necrolysis<br />

(1997): Epstein ME+, JAmAcadDermatol37, 149 (passim)<br />

(1992): McDonald BJ+, Ann Pharmacother 26, 34<br />

Urticaria<br />

(1997): Epstein ME+, JAmAcadDermatol37, 149 (passim)<br />

(1993): de la Fuente-Prieto R+, Allergy 48, 634<br />

(1991): Hantson P+, BMJ 302, 294<br />

(1990): Adkinson NF, Am J Med 88 (Suppl 3C), 12S (0.2%)<br />

(1990): Soto Alvarez J+, Lancet 335, 1094<br />

Mucosal<br />

Aphthous stomatitis (

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