Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

ATAZANAVIR
Trade name: Reyataz (Bristol-Myers Squibb)
Indications: HIV infection
Category: Antiretroviral; Protease inhibitor, HIV
Half-life: 7 hours
Clinically important, potentially hazardous interactions
with: bepridil, cisapride, dasatinib, dofetilide, ergot derivatives,
fentanyl, garlic, indinavir, irinotecan, lapatinib, lovastatin,
marihuana, midazolam, pimozide, proton-pump inhibitors,
rifampin, ritonavir, sildenafil, simvastatin, solifenacin, St John’s
wort, temsirolimus, triazolam
Reactions
Skin
Allergic reactions (sic)
Burning
Cellulitis
Diaphoresis
Eczema
Edema
Fungal dermatitis
Jaundice
(2003): Murphy RL+, AIDS 17(18), 2603
(2003): Sanne I+, J Acquir Immune Defic Syndr 32(1), 18
Pallor
Peripheral edema
Photosensitivity
Pruritus
Purpura
Rash (sic) (20%)
(2006): Ouagari Z+, AIDS 20(8), 1207
(2004): Busti AJ+, Pharmacotherapy 24(12), 1732
Seborrhea
Urticaria
Vesiculobullous eruption
Xerosis
Mucosal
Aphthous stomatitis
Hair
Hair – alopecia
Nails
Nails – changes (sic)
Other
Abdominal pain
(2004): Busti AJ+, Pharmacotherapy 24(12), 1732
Cough
Fever
Gynecomastia
Infections (~50%)
(2004): Busti AJ+, Pharmacotherapy 24(12), 1732
Lipoatrophy
Myalgia/Myositis/Myopathy/Myotoxicity
Neurotoxicity
(2004): Busti AJ+, Pharmacotherapy 24(12), 1732
Pain (3%)
ATENOLOL
Trade names: Antipressan; Apo-Atenol; AteHexal; Atendol;
Evitocor; Noten; Novo-Atenol; Nu-Atenol; Taro-Atenol; Tenolin;
Tenoretic (AstraZeneca); Tenormin (AstraZeneca); Tenormine
Indications: Angina, hypertension, acute myocardial infarction
Category: Adrenergic beta-receptor antagonist; Antiarrhythmic
class II
Half-life: 6–7 hours (adults)
Clinically important, potentially hazardous interactions
with: alfuzosin, cisplatin, clonidine, epinephrine, verapamil
Tenoretic is atenolol and chlorthalidone
Reactions
Skin
Dermatitis
Diaphoresis
Edema
Erythema multiforme
Exanthems
Facial edema
Fixed eruption
(1999): Palungwachira P+, J Med Assoc Thai 82, 1158
Grinspan’s syndrome*
(1990): Lamey PJ+, Oral Surg Oral Med Oral Pathol 70, 184
Hyperkeratosis (palms and soles)
Lichenoid eruption
Lupus erythematosus
(1997): McGuiness M+, JAmAcadDermatol37, 298
(1986): Gouet D+, J Rheumatol 13, 446
Necrosis
Papulo-nodular lesions
(1992): Shelley WB+, Cutis 50, 87 (observation)
Photosensitivity
Pityriasis rubra pilaris
Pruritus (1–5%)
Psoriasis
(2002): Yilmaz MB+, Angiology 53(6), 737
(1990): Wakefield PE+, Arch Dermatol 126, 968 (exacerbation)
(1990): Wolf R, Dermatologica 181, 51
(1988): Gold MH+, JAmAcadDermatol19, 837
(1988): Heng MCY+, Int J Dermatol 27, 619
(1986): Abel EA+, JAmAcadDermatol15, 1007
(1984): Gawkrodger DJ+, Clin Exp Dermatol 9, 92
Purpura
Rash (sic)
(1987): Bolzano K+, J Cardiovasc Pharmacol 9 (Suppl 3), S43
Raynaud’s phenomenon
(1987): Naeyaert JM+, Br J Dermatol 117, 371
Toxic epidermal necrolysis
Urticaria
(1989): Wolf R+, Cutis 43, 231
(1988): Howard PJ+, Scott Med J 33, 344
Vasculitis
(1989): Wolf R+, Cutis 43, 231
Vitiligo
Xerosis
Mucosal
Oral lichenoid eruption
(1990): Lamey PJ+, Oral Surg Oral Med Oral Pathol 70, 184
Hair
Hair – alopecia
(1991): Shelley WB+, Cutis 48, 368 (observation)
ATENOLOL 49