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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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ASPIRIN<br />

Synonyms: acetylsalicylic acid; ASA<br />

Trade names: Aggrenox (Boehringer Ingelheim); Alka-Seltzer;<br />

Anacin (Wyeth); ASA; Ascriptin (Novartis) (Wallace); Aspergum;<br />

Aspro; ASS; Bex; Caprin; Claragine; Coricidin D; Darvon<br />

Compound (aaiPharma); Disprin; Ecotrin (GSK); Empirin;<br />

Equagesic (Women First); Excedrin (Bristol-Myers Squibb);<br />

Fiorinal (Watson); Gelprin; Halfprin; Measurin; Norgesic (3M);<br />

Novasen; Rhonal; Robaxisal; Soma Compound (MedPointe);<br />

Talwin Compound (Sanofi-Aventis); Vanquish<br />

Indications: Pain, fever, inflammation<br />

Category: Antiplatelet; Non-steroidal anti-inflammatory;<br />

Salicylate<br />

Half-life: 15–20 minutes<br />

Clinically important, potentially hazardous interactions<br />

with: anagrelide, anticoagulants, bismuth, boswellia, calcium<br />

hydroxylapatite, capsicum, cholestyramine, devil’s claw,<br />

dexamethasone, dicumarol, etodolac, evening primrose,<br />

flunisolide, ginkgo biloba, ginseng, heparin, ibuprofen,<br />

indomethacin, ketoprofen, ketorolac, lumiracoxib, methotrexate,<br />

methylprednisolone, nilutamide, NSAIDs, phellodendron,<br />

prednisone, resveratrol, reteplase, sermorelin, sulfites,<br />

tirofiban, triamcinolone, urokinase, valdecoxib, valproic acid,<br />

verapamil, warfarin<br />

Aggrenox is aspirin <strong>and</strong> dipyridamole<br />

Reactions<br />

Skin<br />

Acute generalized exanthematous pustulosis (AGEP)<br />

(1993): Ballmer-Weber BK+, Schweiz Med Wochenschr (German)<br />

123, 542<br />

Allergic granulomatous angiitis (Churg–Strauss syndrome)<br />

(1982): Cozzutto C+, Virchows Arch A Pathol Anat Histol 397, 61<br />

Allergic reactions (sic) (

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