Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
(1996): Martinelli L+, Ann Thorac Surg 61, 1288 (1995): Ceriana P+, J Cardiothorac Vasc Anesth 9, 477 (1995): Diefenbach C+, Anesth Analg 80, 830 (1994): Kon NF+, Masui (Japanese) 43, 1606 (1993): Cottineau C+, Ann Fr Anesth Reanim (French) 12, 590 (1993): Schulze K+, Eur J Cardiothorac Surg 7, 495 (2 patients) (1984): BMJ 289, 1696 (1984): LaFerla GA+, BMJ 289, 1176 Hypersensitivity (2002): Jaquiss RD+, Circulation 106(12 Suppl 1), I90 (2000): Beierlein W+, Transfusion 40, 302 (1998): Dietrich W, Ann Thoracic Surg 65, S60 (1.8%) Lipohypertrophy (1985): Boag F+, NEnglJMed312, 245 (in a diabetic) (1985): Dandona P+, Diabetes Res 2, 213 (in a diabetic) Nephrotoxicity (2006): Mangano DT+, NEnglJMed354(4), 353 Phlebitis (1–10%) Thrombosis (2006): Cooper JR+, J Thorac Cardiovasc Surg 131(5), 963 ARBUTAMINE Trade name: GenESA (Sicor) Indications: Diagnostic aid for coronary artery disease Category: Adrenergic beta-receptor agonist Half-life: 1.8 hours Clinically important, potentially hazardous interactions with: abacavir, clidinium, clomipramine, desipramine, dicyclomine, digoxin, doxepin, flavoxate, glycopyrrolate, hyoscyamine, imipramine, mepenzolate, methantheline, nortriptyline, oxybutynin, procyclidine, propantheline, protriptyline, scopolamine, trihexyphenidyl, trimipramine Reactions Skin Diaphoresis (1.5%) Rash (sic) Mucosal Xerostomia (1.1%) Other Application-site reactions (0.1%) Cough (0.2%) Hot flashes (3%) Pain (1.8%) ARGATROBAN Trade name: Acova (GSK) Indications: Heparin-induced thrombocytopenia Category: Thrombin inhibitor Half-life: 40–50 minutes Clinically important, potentially hazardous interactions with: abacavir, butabarbital Skin Allergic reactions (sic) Bullous dermatitis (
42 ARIPIPRAZOLE Myalgia/Myositis/Myopathy/Myotoxicity Pain (2006): Keck PE Jr+, J Clin Psychiatry 67(4), 626 Phlebitis Rhabdomyolysis Tendinopathy/Tendon rupture Thrombophlebitis Upper respiratory infection ARISTOLOCHIA* Scientific names: Aristolochia clematitis; Aristolochia serpentaria Family: Aristolochiaceae Trade and other common names: Birthwort; Long Birthwort; Pelican Flower; Red River Snakeroot; Sangree Root; Sangrel; Serpentaria; Snakeweed; Virginia Serpentary Category: Immunomodulator Purported indications and other uses: Aphrodisiac, antiallergy, anticonvulsant, promotes menstruation Half-life: N/A Other Death Reactions *Note: Aristolochia has been reported to cause severe kidney damage or ‘Chinese herb nephropathy’. Eighteen patients developed carcinomas of the bladder, ureter and/or renal pelvis **Note: Aristolochia is banned in the European Union and Japan ARMODAFINIL Trade name: Nuvigil (Cephalon) Indications: Narcolepsy, obstructive sleep apnea (OSA), shift work sleep disorder Category: Eugeroic wakefulness promoting agent Half-life: 12–15 hours Clinically important, potentially hazardous interactions with: cyclosporine Reactions Skin Allergic reactions (sic) Angioedema Dermatitis (contact) Hyperhidrosis Rash (sic) Stevens–Johnson syndrome Toxic epidermal necrolysis Mucosal Xerostomia Eyes Visual hallucinations Other Abdominal pain Anaphylactoid reactions/Anaphylaxis Anorexia DRESS syndrome Fever Hypersensitivity Pain ARNICA Scientific names: Arnica fulgens; Arnica montana; Arnica sororia Family: Asteraceae; Compositae Trade and other common names: Leopard’s Bane; Mountain snuff; Mountain tobacco; Wolf’s Bane Category: Immunomodulator Purported indications and other uses: Bruising, aches and sprains, insect bites, superficial phlebitis, diuretic, flavoring agent, found in hair tonic and shampoo Half-life: N/A Clinically important, potentially hazardous interactions with: warfarin Reactions Skin Acute febrile neutrophilic dermatosis (Sweet’s syndrome) Adverse effects (sic) (2002): Haller CA+, Adverse Drug React Toxicol Rev 21(3), 143 Allergic reactions (sic) (2002): Knuesel O+, Adv Ther 19(5), 209 (1 case) Dermatitis (2002): Schempp CM+, Hautarzt 53(2), 93 (2001): Int J Toxicol 20, 1 (2001): Reider N+, Contact Dermatitis 45(5), 269 (1980): Hausen BM, Hautarzt 31(1), 10 Irritation (sic) Sensitization (2002): Paulsen E, Contact Dermatitis 47(4), 189 Mucosal Mucosal irritation Mucosal ulceration (1999): Moghadam BK+, Cutis 64(2), 131 (with alcohol and peppermint) Other Death (2001): Int J Toxicol 20, 1 ARSENIC Trade names: Fowler’s Solution (rarely employed; found in pesticides and herbal medicines); Trisonex (Cell Therapeutics) Indications: Acute promyelocytic leukemia, psoriasis (in the early 1900s), devitalization of pulp in dental procedures Category: Trace element Half-life: N/A Clinically important, potentially hazardous interactions with: abacavir, amiodarone, bretylium, chlorpromazine, ciprofloxacin, disopyramide, enoxacin, fluphenazine, gatifloxacin, lomefloxacin, mesoridazine, moxifloxacin, norfloxacin, ofloxacin, phenothiazines, procainamide, prochlorperazine, promethazine, quinidine, quinolones, sotalol, sparfloxacin, thioridazine, trifluoperazine Skin Acral desquamation Reactions
- Page 65 and 66: INDEX OF HERBALS Cola acuminata caf
- Page 67 and 68: INDEX OF HERBS Smilax regelii sarsa
- Page 69 and 70: MAIN CLASSES OF DRUGS ACE inhibitor
- Page 71 and 72: Antiplatelet abciximab aspirin cilo
- Page 73 and 74: MAIN CLASSES OF DRUGS Histamine H1
- Page 76 and 77: ABACAVIR Trade names: Trizivir (GSK
- Page 78 and 79: Xerostomia (2%) Hair Hair - alopeci
- Page 80 and 81: (2006): Santoro D+, Clin Nephrol 66
- Page 82 and 83: Exanthems (2-25%) (1999): Katz HI+,
- Page 84 and 85: ADALIMUMAB Synonym: D2E7 Trade name
- Page 86 and 87: ALBENDAZOLE Trade names: ABZ; Alben
- Page 88 and 89: (2003): Chodorowska G+, Ann Univ Ma
- Page 90 and 91: ALFENTANIL Trade names: Alfenta (Ak
- Page 92 and 93: Lupus erythematosus (1980): Condemi
- Page 94 and 95: Other Abdominal pain (2005): Turgeo
- Page 96 and 97: (1982): van Ketel WG, Contact Derma
- Page 98 and 99: Exanthems Photosensitivity (1984):
- Page 100 and 101: (1980): Lawyer CH+, J Allergy Clin
- Page 102 and 103: Purpura (2%) (1983): Fogoros RN+, C
- Page 104 and 105: (2006): Piller LB+, J Clin Hyperten
- Page 106 and 107: (2006): Gonzalez-Delgado P+, Allerg
- Page 108 and 109: Chills (2004): Martino R, Curr Med
- Page 110 and 111: AMPRENAVIR* Trade name: Agenerase (
- Page 112 and 113: (2001): Ahrendt DM, Am Fam Physicia
- Page 114 and 115: (1999): Ellenberg SS, Center for Bi
- Page 118 and 119: (2003): Uede K+, Br J Dermatol 149(
- Page 120 and 121: ARTEMISIA Scientific names: Artemis
- Page 122 and 123: ASPIRIN Synonyms: acetylsalicylic a
- Page 124 and 125: ATAZANAVIR Trade name: Reyataz (Bri
- Page 126 and 127: (1999): Oakley A, Hamilton, New Zea
- Page 128 and 129: (2002): Robenshtok E+, Isr Med Asso
- Page 130 and 131: Scleroderma (1993): Choy E+, Br J R
- Page 132 and 133: (1997): Epstein ME+, JAmAcadDermato
- Page 134 and 135: Hair Hair - hypertrichosis (3-10%)
- Page 136 and 137: (1997): Banac S+, Acta Paediatr 86(
- Page 138 and 139: BENZALKONIUM Synonyms: parasterol;
- Page 140 and 141: (2002): Gruson LM+, Arch Pediatr Ad
- Page 142 and 143: (2000): Bedikian AY+, Oncol Rep 7,
- Page 144 and 145: BISMUTH Trade names: Bismatrol; Bis
- Page 146 and 147: BLEOMYCIN Synonyms: bleo; BLM Trade
- Page 148 and 149: BLOODROOT Scientific name: Sanguina
- Page 150 and 151: Punctate keratitis (2004): Northing
- Page 152 and 153: BROMFENAC Trade name: Xibrom (ISTA
- Page 154 and 155: Erythema multiforme (
- Page 156 and 157: Myalgia/Myositis/Myopathy/Myotoxici
- Page 158 and 159: (1989): Ackerman WE+, Can J Anaesth
- Page 160 and 161: CALFACTANT Trade name: Infasurf (Fo
- Page 162 and 163: CAPSICUM Scientific names: Capsicum
- Page 164 and 165: Lupus erythematosus (2002): Ratliff
42 ARIPIPRAZOLE<br />
Myalgia/Myositis/Myopathy/Myotoxicity<br />
Pain<br />
(2006): Keck PE Jr+, J Clin Psychiatry 67(4), 626<br />
Phlebitis<br />
Rhabdomyolysis<br />
Tendinopathy/Tendon rupture<br />
Thrombophlebitis<br />
Upper respiratory infection<br />
ARISTOLOCHIA*<br />
Scientific names: Aristolochia clematitis; Aristolochia serpentaria<br />
Family: Aristolochiaceae<br />
Trade <strong>and</strong> other common names: Birthwort; Long Birthwort;<br />
Pelican Flower; Red River Snakeroot; Sangree Root; Sangrel;<br />
Serpentaria; Snakeweed; Virginia Serpentary<br />
Category: Immunomodulator<br />
Purported indications <strong>and</strong> other uses: Aphrodisiac, antiallergy,<br />
anticonvulsant, promotes menstruation<br />
Half-life: N/A<br />
Other<br />
Death<br />
Reactions<br />
*Note: Aristolochia has been reported to cause severe kidney<br />
damage or ‘Chinese herb nephropathy’. Eighteen patients developed<br />
carcinomas of the bladder, ureter <strong>and</strong>/or renal pelvis<br />
**Note: Aristolochia is banned in the European Union <strong>and</strong> Japan<br />
ARMODAFINIL<br />
Trade name: Nuvigil (Cephalon)<br />
Indications: Narcolepsy, obstructive sleep apnea (OSA), shift<br />
work sleep disorder<br />
Category: Eugeroic wakefulness promoting agent<br />
Half-life: 12–15 hours<br />
Clinically important, potentially hazardous interactions<br />
with: cyclosporine<br />
Reactions<br />
Skin<br />
Allergic reactions (sic)<br />
Angioedema<br />
Dermatitis (contact)<br />
Hyperhidrosis<br />
Rash (sic)<br />
Stevens–Johnson syndrome<br />
Toxic epidermal necrolysis<br />
Mucosal<br />
Xerostomia<br />
Eyes<br />
Visual hallucinations<br />
Other<br />
Abdominal pain<br />
Anaphylactoid reactions/Anaphylaxis<br />
Anorexia<br />
DRESS syndrome<br />
Fever<br />
Hypersensitivity<br />
Pain<br />
ARNICA<br />
Scientific names: Arnica fulgens; Arnica montana; Arnica sororia<br />
Family: Asteraceae; Compositae<br />
Trade <strong>and</strong> other common names: Leopard’s Bane; Mountain<br />
snuff; Mountain tobacco; Wolf’s Bane<br />
Category: Immunomodulator<br />
Purported indications <strong>and</strong> other uses: Bruising, aches <strong>and</strong><br />
sprains, insect bites, superficial phlebitis, diuretic, flavoring agent,<br />
found in hair tonic <strong>and</strong> shampoo<br />
Half-life: N/A<br />
Clinically important, potentially hazardous interactions<br />
with: warfarin<br />
Reactions<br />
Skin<br />
Acute febrile neutrophilic dermatosis (Sweet’s syndrome)<br />
Adverse effects (sic)<br />
(2002): Haller CA+, Adverse <strong>Drug</strong> React Toxicol Rev 21(3), 143<br />
Allergic reactions (sic)<br />
(2002): Knuesel O+, Adv Ther 19(5), 209 (1 case)<br />
Dermatitis<br />
(2002): Schempp CM+, Hautarzt 53(2), 93<br />
(2001): Int J Toxicol 20, 1<br />
(2001): Reider N+, Contact Dermatitis 45(5), 269<br />
(1980): Hausen BM, Hautarzt 31(1), 10<br />
Irritation (sic)<br />
Sensitization<br />
(2002): Paulsen E, Contact Dermatitis 47(4), 189<br />
Mucosal<br />
Mucosal irritation<br />
Mucosal ulceration<br />
(1999): Moghadam BK+, Cutis 64(2), 131 (with alcohol <strong>and</strong><br />
peppermint)<br />
Other<br />
Death<br />
(2001): Int J Toxicol 20, 1<br />
ARSENIC<br />
Trade names: Fowler’s Solution (rarely employed; found in<br />
pesticides <strong>and</strong> herbal medicines); Trisonex (Cell Therapeutics)<br />
Indications: Acute promyelocytic leukemia, psoriasis (in the<br />
early 1900s), devitalization of pulp in dental procedures<br />
Category: Trace element<br />
Half-life: N/A<br />
Clinically important, potentially hazardous interactions<br />
with: abacavir, amiodarone, bretylium, chlorpromazine,<br />
ciprofloxacin, disopyramide, enoxacin, fluphenazine, gatifloxacin,<br />
lomefloxacin, mesoridazine, moxifloxacin, norfloxacin, ofloxacin,<br />
phenothiazines, procainamide, prochlorperazine, promethazine,<br />
quinidine, quinolones, sotalol, sparfloxacin, thioridazine,<br />
trifluoperazine<br />
Skin<br />
Acral desquamation<br />
Reactions
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