Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

(1996): Martinelli L+, Ann Thorac Surg 61, 1288
(1995): Ceriana P+, J Cardiothorac Vasc Anesth 9, 477
(1995): Diefenbach C+, Anesth Analg 80, 830
(1994): Kon NF+, Masui (Japanese) 43, 1606
(1993): Cottineau C+, Ann Fr Anesth Reanim (French) 12, 590
(1993): Schulze K+, Eur J Cardiothorac Surg 7, 495 (2 patients)
(1984): BMJ 289, 1696
(1984): LaFerla GA+, BMJ 289, 1176
Hypersensitivity
(2002): Jaquiss RD+, Circulation 106(12 Suppl 1), I90
(2000): Beierlein W+, Transfusion 40, 302
(1998): Dietrich W, Ann Thoracic Surg 65, S60 (1.8%)
Lipohypertrophy
(1985): Boag F+, NEnglJMed312, 245 (in a diabetic)
(1985): Dandona P+, Diabetes Res 2, 213 (in a diabetic)
Nephrotoxicity
(2006): Mangano DT+, NEnglJMed354(4), 353
Phlebitis (1–10%)
Thrombosis
(2006): Cooper JR+, J Thorac Cardiovasc Surg 131(5), 963
ARBUTAMINE
Trade name: GenESA (Sicor)
Indications: Diagnostic aid for coronary artery disease
Category: Adrenergic beta-receptor agonist
Half-life: 1.8 hours
Clinically important, potentially hazardous interactions
with: abacavir, clidinium, clomipramine, desipramine,
dicyclomine, digoxin, doxepin, flavoxate, glycopyrrolate,
hyoscyamine, imipramine, mepenzolate, methantheline,
nortriptyline, oxybutynin, procyclidine, propantheline,
protriptyline, scopolamine, trihexyphenidyl, trimipramine
Reactions
Skin
Diaphoresis (1.5%)
Rash (sic)
Mucosal
Xerostomia (1.1%)
Other
Application-site reactions (0.1%)
Cough (0.2%)
Hot flashes (3%)
Pain (1.8%)
ARGATROBAN
Trade name: Acova (GSK)
Indications: Heparin-induced thrombocytopenia
Category: Thrombin inhibitor
Half-life: 40–50 minutes
Clinically important, potentially hazardous interactions
with: abacavir, butabarbital
Skin
Allergic reactions (sic)
Bullous dermatitis (