Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

40 APRACLONIDINE
Mucosal
Xerostomia (1–10%)
(1987): Abrams DA+, Arch Ophthalmol 105, 1205 (52%)
Eyes
Eyelid edema (0.5%)
Edema (>0.5%)
Rash (sic) (>0.5%)
Stevens–Johnson syndrome
Urticaria
Mucosal
Mucocutaneous reactions (sic)
Sialorrhea (>0.5%)
Hair
Hair – alopecia (>0.5%)
Other
Abdominal pain (>0.5%)
Cough (>0.5%)
Fever
Infections
(2004): Dando TM+, Drugs 64(7), 777
(2003): Chawla SP+, Cancer 97(9), 2290 (13%)
Myalgia/Myositis/Myopathy/Myotoxicity (>0.5%)
Upper respiratory infection (>0.5%)
*Note: Aprepitant treatment is given along with a 5-HT3-receptor
antagonist and dexamethasone
APROBARBITAL
Trade name: Alurate (Roche)
Indications: Short-term sedation, sleep induction
Category: Barbiturate
Half-life: 14–34 hours
Clinically important, potentially hazardous interactions
with: alcohol, brompheniramine, buclizine, dicumarol,
ethanolamine, warfarin
Reactions
Skin
Angioedema
Exanthems
Exfoliative dermatitis
Purpura
Rash (sic)
Stevens–Johnson syndrome
Urticaria
Other
Rhabdomyolysis
(1990): Larpin R+, Presse Med 19(30), 1403
Serum sickness
APROTININ
Trade name: Trasylol (Bayer)
Indications: For prophylactic use to reduce blood loss in patients
undergoing coronary artery bypass surgery
Category: Antifibrinolytic; Protease inhibitor
Half-life: 150 minutes
Reactions
Skin
Allergic reactions (sic) (0.5%)
(1994): Bayo M+, Rev Esp Anestesiol Reanim (Spanish) 41, 123
(1983): Freeman JG+, Curr Med Res Opin 8, 559 (2 cases)
Angioedema
Erythema
Exanthems
(2000): Beierlein W+, Transfusion 40, 302 (generalized)
Pruritus
Rash (sic)
Urticaria
Other
Anaphylactoid reactions/Anaphylaxis (0.5%)
(2007): Kaddoum RN+, J Cardiothorac Vasc Anesth 21(2), 243
(2007): Umeda Y+, Kyobu Geka 60(1), 69
(2005): Shirai T+, Intern Med 44(10), 1088
(2001): Dietrich W+, Anesthesiology 95(1), 64
(2000): Beierlein W, Ann Thorac Surg 69, 1298
(2000): Laxenaire MC+, AnnFrAnesthReanim(French) 19, 96
(2000): Pecquet C+, Ann Fr Anesth 19(10), 755
(1999): Cohen DM+, Ann Thorac Surg 67, 837
(1999): Laxenaire MC, AnnFrAnesthReanim(French) 18, 796 (4
cases)
(1999): Ong BC+, Anaesth Intensive Care 27, 538
(1999): Ryckwaert Y+, AnnFrAnesthReanim(French) 18, 904
(1998): Scheule AM+, Gastrointest Endosc 48, 83
(1997): Dietrich W+, J Thorac Cardiovasc Surg 113, 194
(1997): Orsel I+, AnnFrAnesthReanim(French) 16, 292
(1997): Scheule AM+, Ann Thorac Surg 63, 242