Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

AMPRENAVIR*
Trade name: Agenerase (GSK)
Indications: HIV infection
Category: Antiretroviral; Protease inhibitor, HIV
Half-life: N/A
Clinically important, potentially hazardous interactions
with: amiodarone, amitriptyline, amoxapine, benzodiazepines,
bepridil, clomipramine, clonazepam, clorazepate, delavirdine,
desipramine, diazepam, dihydroergotamine, doxepin,
ergotamine, fentanyl, flurazepam, imipramine, lidocaine,
lorazepam, methysergide, midazolam, nortriptyline, oxazepam,
phenytoin, protriptyline, quazepam, quinidine, rifampin, ritonavir,
sildenafil, St John’s wort, temazepam, tricyclic antidepressants,
trimipramine, vitamin E
Reactions
Skin
Acanthosis nigricans
(2005): Mur A+, Pediatr Infect Dis J 24(8), 742
Exanthems
(2006): Kohli-Pamnani A+, Ann Allergy Asthma Immunol
96(4), 620
Pruritus
Rash (sic) (25%)
(2003): Justesen US+, Br J Clin Pharmacol 55(1), 100 (with
delavirdine)
(2001): Scott T+, Clin Ther 23(2), 252 (8%)
(2000): Conway B+, Expert Opin Investig Drugs 9(2), 371
(2000): Noble S+, Drugs 60(6), 1383
(2000): Pedneault L+, Clin Ther 22(12), 1378 (3%)
Stevens–Johnson syndrome (4%)
(2003): Rotunda A+, Acta Derm Venereol 83(1), 1
Other
Gynecomastia
*Note: Protease inhibitors cause dyslipidemia which includes
elevated triglycerides and cholesterol and redistribution of body fat
centrally to produce the so-called ‘protease paunch,’ breast
enlargement, facial atrophy, and ‘buffalo hump’
**Note: Amprenavir is a sulfonamide and can be absorbed
systemically. Sulfonamides can produce severe, possibly fatal,
reactions such as toxic epidermal necrolysis and Stevens–Johnson
syndrome
AMYL NITRITE
Synonym: isoamyl nitrite
Trade names: Amyl Nitrite; Nitrit
Indications: Angina pectoris
Category: Nitrate; Vasodilator
Half-life: N/A
Clinically important, potentially hazardous interactions
with: furosemide, sildenafil
Reactions
Skin
Allergic reactions (sic)
(1989): Dax EM+, Am J Med 86, 732
Dermatitis
(1985): Bos JD+, Contact Dermatitis 12, 109
(1984): Fisher AA, Cutis 34(2), 118
(1982): Romaguera C+, Contact Dermatitis 8, 266
Diaphoresis
Edema
Pallor
Rash (sic) (