Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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(2006): Piller LB+, J Clin Hypertens 8(9), 649 (Greenwich) (6%) Dermatitis (1–10%) Diaphoresis (10%) (2006): Andersen J+, Am J Ther 13(3), 198 (2006): Hong SJ+, Clin Ther 28(4), 537 (4%) (2004): Wu SC+, Heart Vessels 19(1), 13 (7.5%) (2003): Franco RJ+, Blood Press Suppl Supp 2, 41 (2003): Malacco E+, Clin Ther 25(11), 2765 (27%) (2002): Litt JZ, Beachwood, OH (personal case) (observation) (2001): Lenz TL+, Pharmacotherapy 21(8), 898 (4 cases) (with nisoldipine) (2001): Zanchetti A+, J Cardiovasc Pharmacol 38(4), 642 (1994): Clavijo GA+, Am J Hosp Pharm 51, 59 (1993): Ellis JS+, Lancet 341, 1102 Petechiae (

30 AMOXAPINE AMOXAPINE Trade names: Amoxan; Amoxapine (Watson); Asendis; Defanyl; Demolox Indications: Depression Category: Antidepressant, tetracyclic; Muscarinic antagonist Half-life: 11–30 hours Clinically important, potentially hazardous interactions with: amprenavir, clonidine, epinephrine, guanethidine, isocarboxazid, linezolid, MAO inhibitors, phenelzine, quinolones, sparfloxacin, tranylcypromine Reactions Skin Acne Acute febrile neutrophilic dermatosis (Sweet’s syndrome) (2004): Mecca P+, JCutanPathol31(2), 189 (with citalopram and perphenazine) (photodistributed) Acute generalized exanthematous pustulosis (AGEP) (2004): Mecca P+, JCutanPathol31(2), 189 (1998): Loche F+, Acta Derm Venereol 78, 224 (1994): Larbre B+, Ann Dermatol Venereol (French) 121, 40 Allergic reactions (sic) (1%) Erythema multiforme (observation) (1982): Bishop L, ADRRS oral communication Exanthems (1996): Nagayama H+, JDermatol23, 899 (1982): Jue SG+, Drugs 24, 1 Petechiae Photosensitivity (

30 AMOXAPINE<br />

AMOXAPINE<br />

Trade names: Amoxan; Amoxapine (Watson); Asendis; Defanyl;<br />

Demolox<br />

Indications: Depression<br />

Category: Antidepressant, tetracyclic; Muscarinic antagonist<br />

Half-life: 11–30 hours<br />

Clinically important, potentially hazardous interactions<br />

with: amprenavir, clonidine, epinephrine, guanethidine,<br />

isocarboxazid, linezolid, MAO inhibitors, phenelzine, quinolones,<br />

sparfloxacin, tranylcypromine<br />

Reactions<br />

Skin<br />

Acne<br />

Acute febrile neutrophilic dermatosis (Sweet’s syndrome)<br />

(2004): Mecca P+, JCutanPathol31(2), 189 (with citalopram<br />

<strong>and</strong> perphenazine) (photodistributed)<br />

Acute generalized exanthematous pustulosis (AGEP)<br />

(2004): Mecca P+, JCutanPathol31(2), 189<br />

(1998): Loche F+, Acta Derm Venereol 78, 224<br />

(1994): Larbre B+, Ann Dermatol Venereol (French) 121, 40<br />

Allergic reactions (sic) (1%)<br />

Erythema multiforme (observation)<br />

(1982): Bishop L, ADRRS oral communication<br />

Exanthems<br />

(1996): Nagayama H+, JDermatol23, 899<br />

(1982): Jue SG+, <strong>Drug</strong>s 24, 1<br />

Petechiae<br />

Photosensitivity (

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