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<strong>Protocol</strong> Version 3 14/01/2013 <strong>Protocol</strong> <strong>Title</strong> : A <strong>Randomised</strong>, <strong>open</strong> <strong>labelled</strong> <strong>study</strong> <strong>in</strong> <strong>anti</strong>-TNFa <strong>in</strong>adequate responders to <strong>in</strong>vestigate the mechanisms for Response - Resistance to Rituximab versus Tocilizumab <strong>in</strong> RA (R4-RA) Version: 3 EudraCT reference: 2012-002535-28 Dated: 14 / JANUARY / 2013 CONFIDENTIAL : Further dissem<strong>in</strong>ation of this protocol may only be made with the permission of the Chief Investigator Study: R4RA EudraCT: 2012-002535-28 1 / 34