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Dietary Supplements in Myelodysplastic Syndromes

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Literature Review of antioxidant supplementation<br />

on chemotherapeutic toxicity<br />

• 33 of 965 articles: RCT, met criteria, N=<br />

2,446<br />

• 24/33 reported ↓ toxicities from concurrent<br />

use of antioxidants with chemotherapy.<br />

• 9 reported no difference <strong>in</strong> toxicities<br />

• 1 (vitam<strong>in</strong> A) reported a significant <strong>in</strong>crease<br />

<strong>in</strong> toxicity <strong>in</strong> the antioxidant group<br />

• 5 reported antioxidant group had more full<br />

dose or less dose-reduction than control<br />

groups Into J Cancer. 2008 Sep 15;123(6):1227-39

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