Dietary Supplements in Myelodysplastic Syndromes
Dietary Supplements in Myelodysplastic Syndromes
Dietary Supplements in Myelodysplastic Syndromes
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ß-phenylethyl isothiocyanate<br />
PEITC (Watercress)<br />
• Reactive oxygen species (ROS) stimulate cell<br />
proliferation and <strong>in</strong>duce genetic <strong>in</strong>stability<br />
• Cancer cells make lots of ROS<br />
• PEITC disables glutathione antioxidant<br />
system caus<strong>in</strong>g severe ROS accumulation <strong>in</strong><br />
cancer cells which have high ROS output<br />
• High ROS causes oxidative cell damage and<br />
death of cell.<br />
• Animal studies<br />
Trachootham D. Selective kill<strong>in</strong>g of oncogenically transformed cells through a<br />
ROS mediated mechanism by ß-phenylethyl isothiocyanate. CANCER CELL<br />
2006 10;241–252
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