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Internal Medicine Board Review - DiscWrite CD Promotions

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Chronic Myelogenous Leukemia<br />

CML<br />

• Philadelphia chromosome,t(9;22) producing<br />

b brc/Abl, /Abl protein t i th that t hhas ttyrosine i kinase ki<br />

activity<br />

• PPatients ti t have h llow lleukocyte k t alkaline lk li<br />

phosphatase and splenomegaly*<br />

• LLeukostasis k t i (leucocyte counts > 300,000 mm3): • Headache<br />

• Focal neurologic deficits<br />

• Treatment leukophoresis*

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