Internal Medicine Board Review - DiscWrite CD Promotions
Internal Medicine Board Review - DiscWrite CD Promotions
Internal Medicine Board Review - DiscWrite CD Promotions
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Chronic Myelogenous Leukemia<br />
CML<br />
• Philadelphia chromosome,t(9;22) producing<br />
b brc/Abl, /Abl protein t i th that t hhas ttyrosine i kinase ki<br />
activity<br />
• PPatients ti t have h llow lleukocyte k t alkaline lk li<br />
phosphatase and splenomegaly*<br />
• LLeukostasis k t i (leucocyte counts > 300,000 mm3): • Headache<br />
• Focal neurologic deficits<br />
• Treatment leukophoresis*