Internal Medicine Board Review - DiscWrite CD Promotions

Essential Thrombocythemia
• ET is the most common myeloproliferative
disorder characterized by thrombosis
[arterial and venous] and hemorrhage
– RRemember b th that t th the platelet l t l t count t ddoes not t
correlate with bleeding or clotting*
• Micro Microvascular asc lar thrombi can present with: ith
– Headache, and episodic TIA, dizziness
– Erythromelalgia - pain and dusky extremities
Avoid splenectomy (↑bleeding)
HHydroxyurea d ffor both b th bl bleeding di and d clotting l tti conditions diti
JAK 2 gene occurs in 50% of the patients