Internal Medicine Board Review - DiscWrite CD Promotions
Internal Medicine Board Review - DiscWrite CD Promotions
Internal Medicine Board Review - DiscWrite CD Promotions
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Essential Thrombocythemia<br />
• ET is the most common myeloproliferative<br />
disorder characterized by thrombosis<br />
[arterial and venous] and hemorrhage<br />
– RRemember b th that t th the platelet l t l t count t ddoes not t<br />
correlate with bleeding or clotting*<br />
• Micro Microvascular asc lar thrombi can present with: ith<br />
– Headache, and episodic TIA, dizziness<br />
– Erythromelalgia - pain and dusky extremities<br />
Avoid splenectomy (↑bleeding)<br />
HHydroxyurea d ffor both b th bl bleeding di and d clotting l tti conditions diti<br />
JAK 2 gene occurs in 50% of the patients