Internal Medicine Board Review - DiscWrite CD Promotions
Internal Medicine Board Review - DiscWrite CD Promotions
Internal Medicine Board Review - DiscWrite CD Promotions
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Agnogenic myeloid metaplasia<br />
Myelofibrosis with Myeloid Metaplasia<br />
• Neoplastic stem cells migrate and make marrow in<br />
areas outside of the bone marrow<br />
• Huge splenomegaly (50% with hepatomegaly)<br />
• Teardrop RBCs* due to fibrosis of the bone<br />
marrow<br />
• JAK 2 gene occurs in 50% of myeloid metaplasia,<br />
with or without myelofibrosis<br />
– JAK2 mutation is not part of the diagnostic criteria but it<br />
is supportive