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Internal Medicine Board Review - DiscWrite CD Promotions

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Agnogenic myeloid metaplasia<br />

Myelofibrosis with Myeloid Metaplasia<br />

• Neoplastic stem cells migrate and make marrow in<br />

areas outside of the bone marrow<br />

• Huge splenomegaly (50% with hepatomegaly)<br />

• Teardrop RBCs* due to fibrosis of the bone<br />

marrow<br />

• JAK 2 gene occurs in 50% of myeloid metaplasia,<br />

with or without myelofibrosis<br />

– JAK2 mutation is not part of the diagnostic criteria but it<br />

is supportive

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