Cervical Cancer
Cervical Cancer
Cervical Cancer
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Chemotherapy in advanced &<br />
recurrent cervical cancer<br />
5 randomized trials in 1980 and 1990s<br />
Platinum-based therapies most effective<br />
Cisplatin more active than carboplatin<br />
3 ways to increase response without prolonging survival<br />
– Increase platinum dose<br />
– Add ifosfamide to cisplatin<br />
– Add paclitaxel to cisplatin<br />
Single agent cisplatin 50 mg/m 2 became the best choice<br />
Bonomi F et al, JCO 1985<br />
Thigpen JT et al, Gynecol Oncol 1989<br />
McGure III WP et al, JCO 1989
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