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<strong>CURRICULUM</strong> <strong>VITAE</strong><br />

<strong>Of</strong><br />

<strong>Owen</strong> <strong>Abraham</strong> <strong>Obel</strong>


Name <strong>Owen</strong> A. <strong>Obel</strong><br />

Address 4429 Edmondson Avenue, Dallas,Texas, 75205 USA<br />

Telephone (+1) 214 824 5446 (home)<br />

(+1) 469 831 8950 (cell)<br />

E mail owen.obel@utsouthwestern.edu<br />

Date of Birth 22 May 1962, Johannesburg, South Africa<br />

Nationality South African, UK<br />

US Permanent Resident<br />

Licensure Massachusetts (Full)<br />

Texas (Full)<br />

United Kingdom (Internal Medicine, Cardiology)<br />

South Africa (Internal Medicine, Cardiology)<br />

General Education King Edward VII and Redhill School<br />

Johannesburg, South Africa 1974 - 1980<br />

Medical Education University of Witwatersrand 1981 - 1986<br />

Johannesburg, South Africa<br />

Qualifications MB BCh (MD) Dec 1986<br />

(Honors in Medicine and Pediatrics)<br />

Member of Royal College of Physicians (UK)<br />

Nov 1993<br />

UK - Board certified equivalent (Internal Medicine and<br />

Cardiology)<br />

South Africa – Board certified equivalent (Internal<br />

Medicine and Cardiology)<br />

Thesis University of London 2011 (Doctor of Medicine)<br />

Supervisor: Professor AJ Camm<br />

Title: Thromboembolism in Atrial Fibrillation:<br />

Hemodynamic and Haematologic Mechanisms<br />

2


Current Position<br />

November 2004 - Present<br />

Director of Pacing and Electrophysiology,<br />

Dallas VA Medical Center<br />

Assistant Professor in Medicine and Cardiology<br />

Director of Education - EP Fellowship Program,<br />

<strong>UT</strong> <strong>Southwestern</strong> Medical Center, Dallas, Texas<br />

- Director of fully equipped invasive EP lab at<br />

DVAMC (biplane lab with all standard<br />

equipment including CARTO, ESI and<br />

intracardiac echo) with ± 700 cases performed<br />

annually (approximately 400 devices; 200<br />

standard ablations, 70 AF ablations, 20 VT<br />

ablations/year)<br />

- Responsible for running of EP and Pacing<br />

Service at DVAMC<br />

- Responsible for compiling and running<br />

educational curriculum training of 4 ACGME–<br />

accredited EP Fellows at <strong>UT</strong> <strong>Southwestern</strong>, 2<br />

of whom are full-time at DVAMC<br />

Cardiological Training<br />

EP Fellowship<br />

July 2002 –June 2004 Clinical Fellow in Cardiac Pacing and<br />

Electrophysiology<br />

Cardiac Arrhythmia Service<br />

Massachusetts General Hospital, Boston, USA<br />

Supervisor: Dr Jeremy Ruskin<br />

Cardiology Fellowship St Georges, Hospital, London (and affiliated hospitals)<br />

Oct ’98 – June 2002 Specialist Registrar in Cardiology<br />

Supervisors: Prof AJ Camm; Dr E Rowland<br />

Oct ’2000 – Oct 2001 Specialist Registrar in Cardiology<br />

Sussex Cardiac Centre – Royal Sussex County<br />

Hospital, Brighton, UK<br />

Supervisor: Dr S O ‘Nunain<br />

Oct ’99 – Oct 2000 Specialist Registrar in Cardiology<br />

Mayday University Hospital, London, UK<br />

Supervisor: Dr S Joseph<br />

3


Oct ’98 – Oct ’99 Specialist Registrar in Cardiology<br />

Worthing Hospital, UK<br />

Supervisor: Dr M Signy<br />

Feb ’96 – Oct ’98 Research Fellow in Cardiology, Electrophysiology<br />

St George’s Hospital, London, UK<br />

Supervisor: Professor AJ Camm<br />

Skills<br />

Research Interests<br />

Trained and experienced in all aspects of invasive<br />

electrophysiology.<br />

Trained and experienced in cardiac arrhythmia<br />

ablation including AF and VT ablation (including<br />

epicardial ablation) at 1 st operator level including<br />

frequent current use of electroanatomical mapping<br />

techniques (CARTO and ESI) and intracardiac echo.<br />

Trained and experienced in pacemaker and ICD<br />

implantation and interpretation having performed well<br />

over 1000 such procedures at 1 st operator level.<br />

Trained and experienced in complex and biventricular<br />

device implantation, device revision, and device<br />

upgrades, tunnelling etc, at 1 st operator level.<br />

Trained in transthoracic echocardiography, basic<br />

transesophageal echocardiography, extensive<br />

diagnostic coronary angiography.<br />

Main current research interest: Effect of AV node<br />

ablation and biventricular pacing for refractory AF and<br />

heart failure on atrial electrical remodelling (recently<br />

awarded VISN 17 grant -$100 000).<br />

PI in Dallas for Impulse Dynamics – a study on<br />

Cardiac Contractility Modulation in Heart Failure (FIX<br />

HF 5)<br />

Publications<br />

Camm AJ, <strong>Obel</strong> OA. Epidemiology and mechanism of atrial fibrillation and atrial<br />

flutter. American Journal of Cardiology 1996; 78(8A):3-11<br />

<strong>Obel</strong> OA, Camm AJ. Supraventricular tachycardia. ECG diagnosis and anatomy.<br />

European Heart Journal 1997; 18 Suppl C:C2-11<br />

<strong>Obel</strong> OA, Camm AJ. Accessory pathway reciprocating tachycardia. European<br />

Heart Journal 1998; 19 Suppl E: E13-E24<br />

4


<strong>Obel</strong> OA, Camm AJ. The use of drugs for cardioversion of recent onset atrial<br />

fibrillation and flutter: focus on ibutilide. Drugs & Aging 1998; 12 (6): 461-76<br />

<strong>Obel</strong> OA, Rowland ER. Characteristics and differential diagnosis of arrhythmias.<br />

Chapter in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia. Nava A,<br />

Rossi L, Thiene G (Eds). pp197-209, Elselvier, Amsterdam 1997<br />

<strong>Obel</strong> OA, Camm AJ. Alcohol and the heart. Alcoholism 1998; 17(3): 1-2<br />

<strong>Obel</strong> OA, Camm AJ. Supraventricular Tachycardia. Chapter in Cardiology.<br />

Bayes de Luna A, Brochier M, Dienstl F, Jezek V, Mortensen SA, Poole-Wilson<br />

PA, Braunwald E (Eds). pp191-200, McGraw-Hill, London 1999<br />

<strong>Obel</strong> OA, Camm AJ. Atrioventricular nodal re-entry: prevalence, presentation,<br />

management, and new strategies for intervention in the context of aviation.<br />

European Heart Journal 1999 Suppl D: D98-D104<br />

<strong>Obel</strong> OA, Ward DEW. Advances in Implantable Cardioverter-Defibrillators. Asian<br />

Journal of Cardiology 1999<br />

Gallagher MM, <strong>Obel</strong> OA, Camm AJ. Tachycardia-induced atrial myopathy: an<br />

important mechanism in the pathophysiology of atrial fibrillation? Journal of<br />

Cardiovascular Electrophysiology 1997; 8(9):1065-74<br />

Hnatkova K, <strong>Obel</strong> OA, Camm AJ, Malik M. Technical Advances in Signal-<br />

Averaged Electrocardiography. Cardiac Electrophysiology Review 1997; 1(3):<br />

317-320<br />

Price A. <strong>Obel</strong> OA. Cresswell J. Catch I. Rutter S. Barik S. Heller SR. Weetman<br />

AP. Comparison of thyroid function in pregnant and non-pregnant Asian and<br />

western Caucasian women. Clinica Chimica Acta. 308(1-2):91-8, 2001 Jun<br />

Al-Saady NM, <strong>Obel</strong> OA, Camm AJ. The Left Atrial Appendage: structure,<br />

function, and role in thromboembolism. Heart 1999; 82: 547-555<br />

<strong>Obel</strong> OA. Revisiting established medical options - antiarrhythmic drugs and betablocker<br />

combinations. Resuscitation 2000: 45(3):S7-S10<br />

<strong>Obel</strong> OA, Coltart DJ, Signy M. Balloon Pulmonary Valvuloplasty in Carcinoid<br />

Syndrome. Heart 2000: 83: e2000<br />

<strong>Obel</strong> OA, Camm AJ. Economic Aspects of Implantable-Cardioverter-Defibrillator<br />

Therapy. Chapter in Fighting Sudden Cardiac Death. Aliot E, Clementy J,<br />

Prystowsky E [Eds]. pp 671-688, Futura, Armonk, New York 2000<br />

5


Gallagher MM. Hennessy BJ. Edvardsson N. Hart CM. Shannon MS. <strong>Obel</strong> OA.<br />

Al-Saady NM. Camm AJ. Embolic complications of direct current cardioversion of<br />

atrial arrhythmias: association with low intensity of anticoagulation at the time of<br />

cardioversion. Journal of the American College of Cardiology. 40: 926-33; 2002<br />

<strong>Obel</strong> OA, Davidson C. Arrhythmias in an Athlete: The Effect of De-Training.<br />

Postgraduate Medical Journal; 81:62-64 2005<br />

<strong>Obel</strong> OA, Mansour M, Picard M, Ruskin JR, Keane D Persistence of Septal<br />

Defects After Transeptal Puncture for Pulmonary Vein Isolation Procedures<br />

PACE; 27:1411-1414, 2004<br />

<strong>Obel</strong> OA, Luddington L, Maarouf N, Aytemir K, Ekwall C, Malik M, Camm AJ.<br />

The Effects of Ventricular Rate and Regularity on the Velocity and Magnitude of<br />

Left Atrial Appendage Flow in Atrial Fibrillation. Heart 2005; 91: 764-768<br />

<strong>Obel</strong> OA, d’Avila A, Saad E, Neuzil P, Ruskin R, Reddy V. Ablation of Left<br />

Ventricular Epicardial Outflow Tract Tachycardia from the Distal Great Cardiac<br />

Vein. J Am Coll Cardiol 48:1813-17, 2006<br />

Nesbitt WH, Lampe C, Lustgarten D, <strong>Obel</strong> OA. Supraventricular Tachycardia<br />

with Two VA Intervals: What is the Mechanism? PACE; 30(2):253-5 2007<br />

Chen J, Naseem RH, <strong>Obel</strong> OA, Joglar J. Habitual Cocaine Use Is Associated<br />

with High Defibrillation Threshold During ICD Implantation. Journal of<br />

Cardiovascular Electrophysiology, 18: 722-725, 2007<br />

Brilakis ES, Collins LJ, <strong>Obel</strong> OA, Banerjee S Mechanical valve dysfunction after<br />

percutaneous perimitral leak closure: salvage by percutaneous occluder retrieval.<br />

Catheter Cardiovasc Interv. 75(6):876-81, 2010<br />

Daniels J, Saunders J, Parvethanani S, Byrd A, Joglar J, <strong>Obel</strong> OA.<br />

ICD Electrocardiographic Findings, Device Therapies, and Comorbidities in<br />

Octogenarian Implantable Defibrillator Recipients. Journal of Cardiovascular<br />

Electrophysiology, 21: 236-241, 2010<br />

Kadish A, Nademanee K, Volosin K, Krueger S, Neelagaru S, Raval N, <strong>Obel</strong> O,<br />

Weiner S, Wish M, Carson P, Ellenbogen K, Bourge R, Parides M, Chiacchierini<br />

RP, Goldsmith R, Goldstein S, Mika Y, Burkhoff D, <strong>Abraham</strong> WT. A randomized<br />

controlled trial evaluating the safety and efficacy of cardiac contractility<br />

modulation in advanced heart failure. Am Heart J.161(2):329-337,2011<br />

Daniels JD, Sun S, Zafereo J, Minhajuddin A, Nguyen C, <strong>Obel</strong> O, Wu R, Joglar<br />

JA Preventing shoulder pain after cardiac rhythm management device<br />

implantation: a randomized, controlled study. Pacing Clin Electrophysiol. 2011<br />

Jun;34(6):672-8.<br />

6


Brilakis ES, Lichtenwalter C, Abdel-karim AR, de Lemos JA, <strong>Obel</strong> O, Addo T,<br />

Roesle M, Haagen D, Rangan BV, Saeed B, Bissett JK, Sachdeva R, Voudris<br />

VV, Karyofillis P, Kar B, Rossen J, Fasseas P, Berger P, Banerjee S. Continued<br />

benefit from paclitaxel-eluting compared with bare-metal stent implantation in<br />

saphenous vein graft lesions during long-term follow-up of the SOS (Stenting of<br />

Saphenous Vein Grafts) trial. JACC Cardiovasc Interv. 2011 Feb;4(2):176-82.<br />

<strong>Abraham</strong> WT, Nademanee K, Volosin K, Krueger S, Neelagaru S, Raval N, <strong>Obel</strong><br />

O, Weiner S, Wish M, Carson P, Ellenbogen K, Bourge R, Parides M,<br />

Chiacchierini RP, Goldsmith R, Goldstein S, Mika Y, Burkhoff D, Kadish A; FIX-<br />

HF-5 Investigators and Coordinators. Subgroup analysis of a randomized<br />

controlled trial evaluating the safety and efficacy of cardiac contractility<br />

modulation in advanced heart failure. J Card Fail. 2011 Sep;17(9):710-7.<br />

<strong>Owen</strong>s A, Heinzman K, <strong>Obel</strong> O. Anti-tachycardia pacing as both therapy and<br />

diagnostic tool. What is the diagnosis? Heart Rhythm. 2011 May 25. [Epub ahead<br />

of print]<br />

Lo MY, <strong>Obel</strong> O. Maximizing Cardiac Resynchronization Therapy in Patients With<br />

Atrial Fibrillation. Journal of Innovations in Cardiac Rhythm Management. 2011<br />

(2) 584-593<br />

Letters<br />

<strong>Obel</strong> OA. Cardiological examinations. Journal of the Royal College of Physicians<br />

of London 1997; 31(6):704-5<br />

Abstracts<br />

<strong>Obel</strong> OA, Al-Saady N, Fredericks S, Gallagher M, Waktare J, Camm AJ. Patients<br />

With Non-Valvular Atrial Fibrillation Have Evidence of Thrombin Generation But<br />

Not Endothelial Activation. Journal of the American College of Cardiology 1998;<br />

31 (2A): 332A<br />

<strong>Obel</strong> OA, Treasure T, Murday A, Smith J, Gaer J, Camm AJ. The Effects of Brief<br />

Periods of Acute Atrial Fibrillation on Left Atrial Mechanical Function and<br />

Activation of Coagulation. PACE; 1998, 21 (4) II: 897<br />

<strong>Obel</strong> OA, Treasure T, Murday A, Smith J, Gaer J, Camm AJ. The Effects of<br />

Post-Operative Atrial Fibrillation on Left Atrial Mechanical Function and Activation<br />

of Coagulation. European Heart Journal; 1998, 19 (Suppl): 96<br />

<strong>Obel</strong> OA, Al-Saady N, Luddington L, Murday A, Treasure T, Camm AJ.<br />

Hypercoagulability of Left Atrial Appendage Blood From Patients With Atrial<br />

Fibrillation. European Heart Journal; 1998, 19 (Suppl): 460<br />

7


<strong>Obel</strong> OA, Al-Saady N, Luddington L, Murday A, Treasure T, Camm AJ. Regional<br />

Intra-cardiac Variability of Pre-thrombotic Markers in Patients with Non-valvular<br />

Atrial Fibrillation. Circulation; 1998, 17 (Suppl): 704<br />

<strong>Obel</strong> OA, Aytemir K, Luddington L, Maarouf N, Ekwall C, Malik M, and Camm<br />

AJ; The Efffects of Ventricular Rate and Rhythm on the Velocity and Magnitude<br />

of Left Atrial Appendage Flow in Patients With Atrial Fibrillation. PACE; 1999, 22<br />

(4), 710<br />

<strong>Obel</strong> OA, Aytemir K, Luddington L, Maarouf N, Ekwall C, Malik M, and Camm<br />

AJ; The Relative Effects of Ventricular Rate and Rhythm on Ejection Fraction in<br />

Patients With Atrial Fibrillation, PACE; 1999, 22 (4), 710<br />

<strong>Obel</strong> OA, Aytemir K, Luddington L, Maarouf N, Ekwall C, Malik M, and Camm<br />

AJ; The Efffects of Ventricular Rate and Rhythm on the Velocity and Magnitude<br />

of Left Atrial Appendage Flow in Patients With Atrial Fibrillation, PACE 1999, 22<br />

(4), 842<br />

Gallagher MM, Hart CM, Shannon MS, <strong>Obel</strong> OA, Al-Saady N, Camm AJ.<br />

Embolic Complications of Direct Current Cardioversion of Atrial Arrhythmias.<br />

PACE; 1998, 21 (4) II: 953<br />

M.M. Gallagher, C.M. Hart, M.S Shannon, <strong>Obel</strong> OA, N.M. Al-Saady, A.J. Camm.<br />

Safety of Direct Current Conversion of Atrial Arrhythmias. Journal of the<br />

American College of Cardiology 1998; 31 (2A): 38A<br />

M. M. Gallagher, B.J. Hennessy, C.M. Hart, M.S. Shannon, A.M. Murtagh, <strong>Obel</strong><br />

OA, A.J. Camm. Embolic Complications of Direct Current Cardioversion Reflect<br />

Inadequate Intensity of Anticoagulation Circulation; 1998, 17 (Suppl): 767<br />

<strong>Obel</strong> OA, Mansour M, Picard M, Ruskin JR, Keane D Persistence of Septal<br />

Defects After Transeptal Puncture for Pulmonary Vein Isolation Procedures<br />

NASPE 2004<br />

Abrol R, Nguyen C, Le B, Cogan J, Nesbitt W, Naseem R, Hamden M, Kowal R,<br />

<strong>Obel</strong> OA, Anderson JA, Joglar J. Radiation exposure to physician operators<br />

during biventricular device implants. 2005 Heart Rhythm Society Scientific<br />

Sessions; May 4-7,2005; New Orleans, LA. Abstract P2-114<br />

Nesbitt W, Lampe C, <strong>Obel</strong> OA. Impantation of Left ventricular Pacing Leads<br />

Without the Use of a Sheath Heart Rhythm Journal 2006; 3 (1S) S143<br />

<strong>Obel</strong> IWP, Daniels J, Lokhoff N, Van Wijk F, <strong>Obel</strong> OA. Initial Experience With a<br />

Single Coronary Sinus Lead for Left-Sided Atrioventricular Pacing. Heart Rhythm<br />

Journal 2007 (5S) S25<br />

8


Srinivasan N, Ho J, Naseem R, Joglar J, Collins L, <strong>Obel</strong> OA. AV Node Ablation<br />

and Biventricular Pacing − A Comparison between Ischemic and Non-Ischemic<br />

Cardiomyopathy - Heart Rhythm Journal 2009 5S S463<br />

Ahmed SH, Amin A, Joglar J, <strong>Obel</strong> OA. Does Interatrial Conduction Delay<br />

Preclude Atrioventricular Optimization in Cardiac Resynchronization Therapy,<br />

and Would a Left Atrial Bipole Help? - Heart Rhythm Journal 2009 5S S188<br />

Torres-Heisecke R, Dimas,V MD; <strong>Owen</strong>s A, Joglar,J; <strong>Obel</strong> OA. Unexpected<br />

Restoration of Sinus Rhythm After Atrioventricular Node Ablation and<br />

Biventricular Pacing in Heart Failure Patients With Atrial Fibrillation. (ACC March<br />

2010)<br />

Presentations, Lectureship<br />

September 1999 – ‘Fighting Sudden Cardiac Death – a Worldwide Challenge’,<br />

Palais de Congress, Paris – 3 lectures on behalf of Prof AJ Camm<br />

Numerous presentations at international meetings including AHA, ACC,<br />

NASPE/HRS, The British Cardiac Society, and the European Society of<br />

Cardiology (see ‘Abstracts’)<br />

Internal Medicine Grand Rounds, <strong>UT</strong> <strong>Southwestern</strong>, Dallas, Texas, March 2006,<br />

January 2011<br />

Internal Medicine Grand Rounds, Presbyterian Hospital, Dallas, Texas, March<br />

2006<br />

Regular presenter at IBHRE Exam Review Courses<br />

Numerous lectures delivered for Pacing/ICD/ablation catheter corporations at<br />

sponsored symposia<br />

Presenter at core curricula sessions at HRS scientific sessions in 2007 and 2008;<br />

session chairman in 2009, 2010<br />

Other Previous Training<br />

General Medicine<br />

Feb’94 – Jan’96 Registrar in General Medicine<br />

Trent Regional Health Authority, UK<br />

Feb ’93 – Jan ’94 Senior House <strong>Of</strong>ficer, Medicine<br />

Kent & Canterbury Hospital, UK<br />

Aug ’92 – Jan ’93 Senior House <strong>Of</strong>ficer in Medicine<br />

9


Bradford Royal Infirmary, UK<br />

Aug ’91 – Mar ’92 Senior House <strong>Of</strong>ficer in Medicine<br />

William Harvey Hospital, Ashford, UK<br />

Feb ’91 – July ’91 Senior House <strong>Of</strong>ficer, Orthopedics<br />

William Harvey Hospital, Ashford, UK<br />

Feb ’89 – Jan ‘91 Compulsory Military Service (MD in a Mission Hospital<br />

in Zululand, South Africa)<br />

1 Jan ‘88 – 30 June ‘88 Senior House <strong>Of</strong>ficer, Medicine<br />

Hillbrow Hospital, Johannesburg, South Africa<br />

1 Jan ‘87 – 31 Dec ‘87 Internship (Medicine and Surgery)<br />

Hillbrow Hospital, Johannesburg, South Africa<br />

Other interests<br />

Family, music, travel, photography<br />

Referees<br />

Dr Vivek Reddy<br />

Mount Sinai Medical Center<br />

1190 5 th Avenue<br />

1 st Floor, New York, NY 10029<br />

Tel: 212 241 7114<br />

Professor A John Camm<br />

Department of Cardiological Sciences<br />

St George’s Hospital Medical School<br />

LONDON<br />

SW17 0RE<br />

UK<br />

Tel: (+44) 208 725 3554<br />

Dr Jeremy Ruskin<br />

Cardiac Arrhythmia Service<br />

Massachusetts General Hospital<br />

55 Fruit Street<br />

Boston<br />

02130<br />

Massachusetts<br />

USA<br />

Tel: 617 726 2000<br />

10

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