SIEVE User Guide

A Understanding the ChromAlign Process
Aligning Over Chromalign Time Shifts
Aligning Over Chromalign Time Shifts
See Figure 22 to understand the complexity of the alignment process by plotting the
chromatographic time warping function. Although this plot uses data from a different set of
control and sample files, it demonstrates the complexity of the alignment effort caused by
chromatographic shifts. The average alignment score for the alignment in this figure is 0.53.
Figure 22. Chromatographic time warping required to create alignment
Time Warp
0 5 10 15
100 200 300 400 500
Time (Min)
34 SIEVE User Guide Thermo Fisher