SIEVE User Guide
SIEVE User Guide
SIEVE User Guide
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A Understanding the ChromAlign Process<br />
Aligning Over Different Abundance Levels<br />
Aligning Over Different Abundance Levels<br />
Biomarker discovery detects low abundance components in the presence of high abundance<br />
components that remain essentially unchanged between the controls and samples. The<br />
following example shows the alignment of low abundance components in the presence of high<br />
abundance components. Figure 20 shows reconstructed ion chromatograms of a horse<br />
myoglobin peptide added to the nine-protein mix at three different concentrations (500 fmol<br />
[red], 250 fmol [green], and 100 fmol [blue]) and compared to the control sample (1000 fmol<br />
[black]).<br />
Figure 20. Original reconstructed ion chromatograms<br />
Abundance<br />
0 50000 100000 150000<br />
49 50 51<br />
Time (Min)<br />
52 53<br />
32 <strong>SIEVE</strong> <strong>User</strong> <strong>Guide</strong> Thermo Fisher
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