welcome to the book! - my education - login - Dermalogica
welcome to the book! - my education - login - Dermalogica welcome to the book! - my education - login - Dermalogica
skin dermalogica health AGE smart smart | retail products | product name 78 dermalogica ® | retail products 78 AGE smart ® Wrinkles, altered pigmentation, loss of skin tone… we all associate these changes with skin aging. Age-related skin changes are the result of geneticallyprogrammed changes (intrinsic factors) and environmental wear-and-tear on the skin (extrinsic factors). While both influence the skin’s structure and function, extrinsic factors cause more pronounced changes. Estimates state that 80-99% of what we see on our skin as adults is the result of exposure to daylight, which is referred to as photoaging. Manifestations of photoaging include an increase in wrinkle formation, a loss of tension and elasticity, degeneration of the vascular supply and skin thickness, a reduction in the water-binding properties of the skin, dilated capillaries (telangiectasis), hyperpigmentation and other skin discoloration. While scientists attribute the majority of these structural changes to exposure to ultraviolet (UV) radiation, it has only been in recent years that they have come to understand the actual biochemical
UV exposure fibroblasts UV exposure and inflammatory modulators activation of MMP genes in fibroblast triggers that instigate these changes. These are chemical reactions that occur within the skin and include: • Generation of Reactive Oxygen Species (ROS), also known as free radicals. • Activation of metalloproteinase enzymes (Matrix Metalloproteinases or MMPs) with a subsequent decline in collagen biosynthesis. • Glycation leading to Advanced Glycation End-products (AGEs). The treatment of skin aging used to rely on addressing the structural manifestations of photoaged skin, such as wrinkles and loss of elasticity. Today, we can more effectively treat this skin condition by addressing the actual biochemical reactions that trigger these structural changes. Obviously, understanding these specific biochemical epidermis dermis enzymes and proteins are synthesized in fibroblast MMP enzyme (collagenase) reactions is key to treating the structural changes associated with skin aging. Let’s examine these structural changes that occur in the epidermis and dermis, as well as the biochemical reactions that trigger them. Biochemical Reactions that Cause Skin Aging Generation of Reactive Oxygen Species (ROS) Reactive Oxygen Species include oxygen ions, free radicals and peroxides. ROS are generally very small molecules and are highly reactive due to the presence of unpaired electrons. They form as a natural by-product of the normal metabolism of oxygen. During times of environmental stress, ROS levels can increase dramatically, causing significant damage to cell structures. This is known further degradation of collagen disorganized collagen clumping cross-linked collagen collagen MMP breaks down collagen and inhibits formation of new collagen 1. MMP enzymes are activated within the fibrobla nucleus by UV light or inflammatory modulators. 2. MMPs, such as collagenase, are synthesized in the fibroblast. 3. MMPs (collagenase) break down collagen and inhibit formation of new collagen. 4. Collagen is degraded into gelatinous peptides that are further degraded by other MMPs. Cross-linking of collagen also occurs, causing wrinkling and stiffening of skin. as oxidative stress, which is the major cause of degenerative disorders including aging and disease. Studies have shown that UV-induced damage to the skin is in part caused by Reactive Oxygen Species. Lipid peroxidation also results from ROS damage to cell membranes, leading to premature aging, skin cancer and cell death. Activation of Matrix Metalloproteinases (MMPs) Matrix Metalloproteinases are enzymes that, when activated, control tissue degradation in the dermis. MMPs include collagenase that specifically decomposes particular collagens or other proteins in the extracellular matrix of the dermis. Collagenase is really a group of enzymes that are responsible for breaking down the different types of collagen and elastin. the book dermalogica AGE smart ® | retail products 79 skin health | retail products | category
- Page 27 and 28: skin condition Dry, dehydrated or p
- Page 29 and 30: skin condition All skin conditions.
- Page 31 and 32: masques Enhance the daily skin care
- Page 33 and 34: skin condition Skin with excess oil
- Page 35 and 36: concentrated boosters Concentrated
- Page 37 and 38: skin condition Sensitive and sensit
- Page 39 and 40: skin condition All skin conditions,
- Page 41 and 42: skin condition Sensitive and enviro
- Page 43 and 44: skin condition All skin conditions.
- Page 45 and 46: skin condition Dry or prematurely-a
- Page 47 and 48: skin condition All skin conditions.
- Page 49 and 50: skin condition All skin conditions.
- Page 51 and 52: skin condition All skin conditions,
- Page 53 and 54: notes the book dermalogica | retail
- Page 55 and 56: professional exfoliation The human
- Page 57 and 58: the dermalogica exfoliation level s
- Page 59 and 60: level 1 level 2 level 3 exfoliation
- Page 61 and 62: Mix Exfoliant Accelerator 35 with o
- Page 63 and 64: skin condition Dry, prematurely-agi
- Page 65 and 66: skin condition Sensitized, mature,
- Page 67 and 68: skin condition Congested areas of s
- Page 69 and 70: professional massage Massage is one
- Page 71 and 72: skin condition Dry or prematurely-a
- Page 73 and 74: skin condition Sensitive and sensit
- Page 75 and 76: skin condition Sensitive and sensit
- Page 77: skin condition Dry or prematurely-a
- Page 81 and 82: That is when topically-applied cosm
- Page 83 and 84: skin condition Mature or prematurel
- Page 85 and 86: skin condition Mature or prematurel
- Page 87 and 88: skin condition Mature or prematurel
- Page 89 and 90: skin condition Mature or prematurel
- Page 91 and 92: skin condition Mature or prematurel
- Page 93 and 94: skin condition Mature or prematurel
- Page 95 and 96: skin condition All skin conditions,
- Page 97 and 98: skin condition Dry, sun damaged, ma
- Page 99 and 100: skin condition Mature or prematurel
- Page 101 and 102: looking to treat hyperpigmentation
- Page 103 and 104: skin condition Hyperpigmented skin
- Page 105 and 106: skin condition Hyperpigmented skin
- Page 107 and 108: skin condition Hyperpigmented skin
- Page 109 and 110: ChromaWhite TRx ® professional Chr
- Page 111 and 112: notes the book dermalogica ChromaWh
- Page 113 and 114: inflammatory diseases one key facto
- Page 115 and 116: skin condition Sensitized, reactive
- Page 117 and 118: skin condition Sensitized, reactive
- Page 119 and 120: skin condition Sensitized, reactive
- Page 121 and 122: skin condition Sensitized, reactive
- Page 123 and 124: skin condition Sensitized, reactive
- Page 125 and 126: notes the book dermalogica UltraCal
- Page 127 and 128: which can be particularly frustrati
skin dermalogica health AGE smart smart | retail products | product name 78 dermalogica<br />
® | retail products 78<br />
AGE smart ®<br />
Wrinkles, altered pigmentation, loss<br />
of skin <strong>to</strong>ne… we all associate <strong>the</strong>se<br />
changes with skin aging. Age-related<br />
skin changes are <strong>the</strong> result of geneticallyprogrammed<br />
changes (intrinsic fac<strong>to</strong>rs)<br />
and environmental wear-and-tear<br />
on <strong>the</strong> skin (extrinsic fac<strong>to</strong>rs). While<br />
both influence <strong>the</strong> skin’s structure<br />
and function, extrinsic fac<strong>to</strong>rs cause<br />
more pronounced changes. Estimates<br />
state that 80-99% of what we see<br />
on our skin as adults is <strong>the</strong> result of<br />
exposure <strong>to</strong> daylight, which is referred<br />
<strong>to</strong> as pho<strong>to</strong>aging. Manifestations of<br />
pho<strong>to</strong>aging include an increase in<br />
wrinkle formation, a loss of tension and<br />
elasticity, degeneration of <strong>the</strong> vascular<br />
supply and skin thickness, a reduction<br />
in <strong>the</strong> water-binding properties of <strong>the</strong><br />
skin, dilated capillaries (telangiectasis),<br />
hyperpigmentation and o<strong>the</strong>r skin<br />
discoloration.<br />
While scientists attribute <strong>the</strong> majority of<br />
<strong>the</strong>se structural changes <strong>to</strong> exposure<br />
<strong>to</strong> ultraviolet (UV) radiation, it has only<br />
been in recent years that <strong>the</strong>y have come<br />
<strong>to</strong> understand <strong>the</strong> actual biochemical