A5V4d

Number
of
studies
1
(Teach,
1995)
1 (Bang,
2009)
Score of ≥ 16
Number
of
children
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
6680 1 (0 to 2) b 99 (99 to 99)
b
219 48 (27 to
56)
For detecting serious illness
1
(McCart
hy,
1982)
312 33 (18 to
49) a
For detecting serious bacterial infection
1
(Andreol
a, 2007)
Positive
predictive
value
(95%
confidence
interval)
91 (67 to 90) 68 (52 to
82)
99 (98 to
100) a
408 9 (3 to 14) a 98 (96 to 99)
a
Clinical assessment of the child with fever
Negative
predictive
value
(95%
confidence
interval)
1 (0 to 4) b 97. (97 to
97) b
92 (78 to
100) a
53 (28 to
79) a
NA Not applicable
a Calculated by the NCC-WCH from results reported in the study
82 (75 to
87)
89 (85 to
93) a
78 (74 to
82) a
b Confidence intervals calculated by the NCC-WCH from data reported in the study
Table 5.47 GRADE profile for comparison of Yale Observation Scores
Number
of
studies
Positive
likelihood
ratio
(95%
confidence
interval)
0.4 (0.1 to
3.2) a
5.5 (3.0 to
9.8)
64.7 (8.7 to
482.0) a
3.8 (1.4 to
10.3) a
Negative
likelihood
ratio
(95%
confidence
interval)
1.0 (1.0 to
1.0) a
0.6 (0.4 to
0.7)
0.7 (0.5 to
0.8) a
0.9 (0.9 to
1.0) a
Duration of fever Effect Quality
With serious
bacterial
illness/infectio
n (SBI) (Mean,
SD)
Yale Observation Score
For detecting serious bacterial infection
1 (Hsiao,
2006)
Without SBI (Mean, SD) P value
9.4 (SD 4.6) 8.1 (SD 3.6) P < 0.05 High
For detecting bacteraemia
1
(Haddon,
1999)
7.0 (SD 1.5) 7.4 (SD 1.9) P = 0.45 High
P probability, SBI serious bacterial illness/infection, SD standard deviation
Evidence statements
The following definitions have been used when summarising the likelihood ratios:
Quality
Very
low
Modera
te
Convincing: positive likelihood ratio (LR+) 10 or higher, negative likelihood ratio (LR-)
0.1 or lower
Strong: LR+ 5 or higher (but less than 10), LR- 0.2 or lower (but higher than 0.1)
Not strong: LR+ 4.9 or lower, LR- higher than 0.2
Low
Low
91
2013 Update