A5V4d

Table 5.46 GRADE profile for evaluation of Yale Observation Scale
Number
of
studies
Number
of
children
Score of 3 or 4
Sensitivity
(95%
confidence
interval)
For detecting serious illness
1
(McCart
hy,
1981)
1
(McCart
hy,
1981)
1
(McCart
hy,
1981)
Score of 4 or 5
312 67 (45 to
88) a
312 56 (33 to
79) a
312 72 (52 to
93) a
For detecting bacteraemia
1
(Haddon
, 1999)
Score of 5, 6, or 7
Specificity
(95%
confidence
interval)
79 (74 to 84)
a
89 (85 to 93)
a
79 (74 to 84)
a
534 6 (0 to 16) a 95 (92 to 97)
a
For detecting bacterial illness or pneumonia
1
(McCart
hy,
1980)
1
(McCart
hy,
1980)
Score > 6
219 60 (35 to
85) a
219 27 (4 to 49)
a
For detecting bacteraemia
1
(Teach,
1995)
Score > 8
6680 29 (22 to
35) b
For detecting bacteraemia
1
(Teach,
1995)
1 (Bang,
2009)
6680 17 (11 to
22) b
219 97 (79 to
99)
76 (70 to 82)
a
94 (91 to 97)
a
83 (82 to 83)
b
92 (91. to
93) b
Positive
predictive
value
(95%
confidence
interval)
19 (9 to 29)
a
27 (13 to
41) a
20 (10 to
30) a
Clinical assessment of the child with fever
Negative
predictive
value
(95%
confidence
interval)
97 (95 to
99) a
96 (94 to
99) a
97 (95 to
100) a
5 (0 to 15) a 95 (93 to
97) a
16 (6 to 25)
a
25 (4 to 46)
a
66 (55 to 72) 52 (43 to
62)
96 (93 to
99) a
95 (91 to
98) a
5 (3 to 6) b 97 (97 to
98) b
6 (4 to 8) b 97 (97 to
98) b
98 (93 to
100)
Positive
likelihood
ratio
(95%
confidence
interval)
3.2 (2.1 to
4.8) a
5.0 (2.9 to
8.7) a
3.5 (2.4 to
5.0) a
1.0 (0.1 to
7.4) a
2.5 (1.5 to
4.0) a
4.5 (1.7 to
12.4) a
1.6 (1.3 to
2.1) a
2.0 (1.5 to
2.8) a
2.8 (2.2 to
3.5)
Negative
likelihood
ratio
(95%
confidence
interval)
0.4 (0.2 to
0.8) a
0.5 (0.3 to
0.8) a
0.4 (0.2 to
0.7) a
1.0 (0.9 to
1.1) a
0.5 (0.3 to
1.0) a
0.8 (0.6 to
1.1) a
0.9 (0.8 to
0.9) a
0.9 (0.9 to
1.0) a
0.1 (0.0 to
0.2)
Quality
Very
low
Very
low
Very
low
Low
Very
low
Very
low
Very
low
Very
low
Modera
te
89