A5V4d

Feverish illness in children
Table 5.43 GRADE profile for evaluation of urinary symptoms
Number
of
studies
88
Number
of
children
Urinary symptoms
Sensitivity
(95%
confidence
interval)
For detecting serious bacterial infection
1 (Craig,
2010)
1
(Nijman,
2011)
15781 5 (4 to 6) a
Specificity
(95%
confidence
interval)
98 (98 to
98) a
1255 8 (4 to 13) a 99 (98 to
99) a
Positive
predictive
value
(95%
confidence
interval)
17 (13 to
21) a
41 (22 to
59) a
a Calculated by the NCC-WCH based on data reported in the study
Negative
predictive
value
(95%
confidence
interval)
93 (93 to
93) a
90 (89 to
92) a
Table 5.44 GRADE profile for evaluation of abnormal ear, nose and throat signs
Number
of
studies
Number
of
children
Sensitivity
(95%
confidence
interval)
Abnormal ear, nose and throat signs
For detecting serious bacterial infection
1 (Craig,
2010)
Ear problems
15781 42 (39 to
45) a
Serious bacterial infection
1
(Nijman,
2011)
Specificity
(95%
confidence
interval)
45 (44 to 46)
a
1255 4 (1 to 7) a 99 (98 to 99)
a
Positive
predictive
value
(95%
confidence
interval)
Negative
predictive
value
(95%
confidence
interval)
6 (5 to 6) a 91 (90 to
92) a
17 (3 to 31)
a
a Calculated by the NCC-WCH based on data reported in the study
Table 5.45 GRADE profile for evaluation of rigor and/or chills
Number
of
studies
Rigors
Number
of
children
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
For detecting confirmed or presumed bacterial illness
1 (Tal,
1997)
434 28 (23 to
34) a
83 (78 to 89)
a
Positive
predictive
value
(95%
confidence
interval)
67 (78 to
95) a
94 (93 to
95) a
Negative
predictive
value
(95%
confidence
interval)
49 (44 to
55) a
Positive
likelihood
ratio
(95%
confidence
interval)
2.7 (2.0 to
3.6) a
5.9 (2.8 to
12.4) a
Positive
likelihood
ratio
(95%
confidence
interval)
0.8 (0.7 to
0.8) a
3.2 (1.2 to
8.3) a
Positive
likelihood
ratio
(95%
confidence
interval)
1.7 (1.2 to
2.5) a
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
Negative
likelihood
ratio
(95%
confidence
interval)
1.0 (1.0 to
1.0) a
0.9 (0.9 to
1.0) a
Negative
likelihood
ratio
(95%
confidence
interval)
1.3 (1.2 to
1.4) a
1.0 (0.9 to
1.0) a
Negative
likelihood
ratio
(95%
confidence
interval)
0.9 (0.8 to
1.0) a
Quality
Low
Quality
Low
Very
low
Quality
Very
low