A5V4d

Table 5.40 GRADE profile for evaluation of abnormal neurological findings
Number
of
studies
Number
of
children
Sensitivity
(95%
confidence
interval)
Abnormal neurological findings
For detecting bacterial meningitis
1 (Joffe,
1983)
1
(Offringa
, 1992)
Neurological deficit
241 92 (78 to
100) a
92 64 (44 to
84) a
For detecting bacterial meningitis
1 (Batra,
2011)
199 80 (45 to
100) a
Specificity
(95%
confidence
interval)
84 (79 to 89)
a
91 (88 to 94)
a
99 (98 to
100) a
Positive
predictive
value
(95%
confidence
interval)
25 (13 to
37) a
35 (20 to
50) a
80 (45 to
100) a
a Calculated by the NCC-WCH based on data reported in the study
Table 5.41 GRADE profile for evaluation of impression of tone
Number
of
studies
Number
of
children
Impression of tone
For detecting bacteraemia
1 (Crain,
1982)
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
Clinical assessment of the child with fever
Negative
predictive
value
(95%
confidence
interval)
99 (98 to
100) a
97 (95 to
99) a
99 (98 to
100) a
Negative
predictive
value
(95%
confidence
interval)
Positive
likelihood
ratio
(95%
confidence
interval)
5.8 (4.2 to
8.2) a
7.0 (4.3 to
11.4) a
155.2 (20.9
to 1150.8) a
Positive
likelihood
ratio
(95%
confidence
interval)
Negative
likelihood
ratio
(95%
confidence
interval)
0.1 (0.0 to
0.6) a
0.4 (0.2 to
0.7) a
0.2 (0.0 to
1.2) a
Negative
likelihood
ratio
(95%
confidence
interval)
175 NR a NR a NR a NR a NR a NR a Low
NR Not reported
a Text in the paper stated that impression of tone is not significantly associated with bacteraemia
Table 5.42 GRADE profile for evaluation of tenderness on examination
Number
of
studies
Number
of
children
Sensitivity
(95%
confidence
interval)
Tenderness on examination
For detecting urinary tract infection
1 (Shaw,
1998)
Specificity
(95%
confidence
interval)
2411 5 (0 to 10) a 99 (98 to 99)
a
Positive
predictive
value
(95%
confidence
interval)
13 (1 to 26)
a
a Calculated by the NCC-WCH based on data reported in the study
Negative
predictive
value
(95%
confidence
interval)
97 (96 to
98) a
Positive
likelihood
ratio
(95%
confidence
interval)
4.5 (1.6 to
12.5) a
Negative
likelihood
ratio
(95%
confidence
interval)
1.0 (0.9 to
1.0) a
Quality
Very
low
Very
low
Very
low
Quality
Quality
Low
87