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Table 5.34 GRADE profile for evaluation of crying on micturition/dysuria<br />

Number<br />

of<br />

studies<br />

Number<br />

of<br />

children<br />

Sensitivity<br />

(95%<br />

confidence<br />

interval)<br />

Crying on micturition/dysuria<br />

For detecting urinary tract infection<br />

1<br />

(Rabasa<br />

Al, 2009)<br />

145 10 (0 to 23)<br />

a<br />

Specificity<br />

(95%<br />

confidence<br />

interval)<br />

86 (79 to<br />

92) a<br />

Positive<br />

predictive<br />

value<br />

(95%<br />

confidence<br />

interval)<br />

10 (0 to 23)<br />

a<br />

Clinical assessment of the child with fever<br />

Negative<br />

predictive<br />

value<br />

(95%<br />

confidence<br />

interval)<br />

86 (79 to<br />

92) a<br />

Positive<br />

likelihood<br />

ratio<br />

(95%<br />

confidence<br />

interval)<br />

0.7 (0.2 to<br />

2.8) a<br />

a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study<br />

Table 5.35 GRADE profile for evaluation of headache<br />

Number<br />

of<br />

studies<br />

Headache<br />

Number<br />

of<br />

children<br />

Sensitivity<br />

(95%<br />

confidence<br />

interval)<br />

For detecting bacterial meningitis<br />

1<br />

(Ghotbi,<br />

2009)<br />

254 17 (0 to 38)<br />

a<br />

Specificity<br />

(95%<br />

confidence<br />

interval)<br />

100 (99 to<br />

100) a<br />

Positive<br />

predictive<br />

value<br />

(95%<br />

confidence<br />

interval)<br />

67 (13 to<br />

100) a<br />

Negative<br />

predictive<br />

value<br />

(95%<br />

confidence<br />

interval)<br />

96 (94 to<br />

98) a<br />

Positive<br />

likelihood<br />

ratio<br />

(95%<br />

confidence<br />

interval)<br />

40.3 (3.9 to<br />

414.3) a<br />

a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study<br />

Table 5.36 GRADE profile for evaluation of conjunctivitis<br />

Number<br />

of<br />

studies<br />

Conjunctivitis<br />

Number<br />

of<br />

children<br />

Sensitivity<br />

(95%<br />

confidence<br />

interval)<br />

For detecting urinary tract infection<br />

1<br />

(Newma<br />

n, 2002)<br />

1666 1 (1 to 2) a<br />

Specificity<br />

(95%<br />

confidence<br />

interval)<br />

99 (99 to<br />

100) a<br />

Positive<br />

predictive<br />

value<br />

(95%<br />

confidence<br />

interval)<br />

Negative<br />

predictive<br />

value<br />

(95%<br />

confidence<br />

interval)<br />

7 (6 to 21) a 90 (89 to<br />

92) a<br />

Positive<br />

likelihood<br />

ratio<br />

(95%<br />

confidence<br />

interval)<br />

0.7 (0.1 to<br />

5.5) a<br />

a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study<br />

Negative<br />

likelihood<br />

ratio<br />

(95%<br />

confidence<br />

interval)<br />

1.1 (0.9 to<br />

1.2) a<br />

Negative<br />

likelihood<br />

ratio<br />

(95%<br />

confidence<br />

interval)<br />

0.8 (0.6 to<br />

1.1) a<br />

Negative<br />

likelihood<br />

ratio<br />

(95%<br />

confidence<br />

interval)<br />

1.0 (1.0 to<br />

1.0) a<br />

Quality<br />

Low<br />

Quality<br />

Very<br />

low<br />

Quality<br />

Low<br />

85

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