A5V4d

Table 5.32 GRADE profile for evaluation of vomiting
Number
of
studies
Vomiting
Number
of
children
Sensitivity
(95%
confidence
interval)
For detecting serious bacterial infection
1
(Bleeker,
2007)
1
(Bleeker,
2001)
381 49 (40 to
59) a
231 37 (30 to
44) a
For detecting serious disease
1
(Nademi
, 2001)
141 59 (43 to
73)
For detecting bacterial illness
1
(Trautne
r, 2006)
Specificity
(95%
confidence
interval)
69 (64 to 75)
a
43 (30 to 56)
a
60 (50 to 69)
Positive
predictive
value
(95%
confidence
interval)
36 (28 to
44) a
66 (57 to
75) a
38 (25 to
49)
Clinical assessment of the child with fever
Negative
predictive
value
(95%
confidence
interval)
80 (75 to
85) a
19 (12 to
25) a
78 (68 to
87)
Positive
likelihood
ratio
(95%
confidence
interval)
1.6 (1.2 to
2.1) a
0.7 (0.5 to
0.9) a
1.5 (1.0 to
2.1) a
Negative
likelihood
ratio
(95%
confidence
interval)
0.7 (0.6 to
0.9) a
1.5 (1.1 to
2.0) a
0.7 (0.5 to
1.0) a
Quality
Low
Very
low
Very
low
103 NR b NR b NR b NR b NR b NR b Very
low
For detecting urinary tract infection
1
(Morris,
2007)
1
(Rabasa
Al, 2009)
98 NR c NR c NR c NR c NR c NR c Low
145 60 (39 to
81) a
For detecting bacterial meningitis
1
(Ghotbi,
2009)
1
(Offringa
, 1992)
254
67 (40 to
93) a
92 48 (27 to
68) a
For detecting meningococcal disease
1
(Nielsen,
2001)
208 44 (28 to
59) a
60 (51 to 69)
a
100 (100 to
100) a
81 (72 to 90)
a
60 (52 to 67)
a
19 (10 to
29) a
100 (100 to
100) a
46 (26 to
66) a
20 (12 to
29) a
90 (84 to
97) a
98 (97 to
100) a
82 (73 to
91) a
82 (75 to
89) a
1.5 (1.0 to
2.3) a
NC
2.5 (1.3 to
4.9) a
1.1 (0.7 to
1.6) a
0.7 (0.4 to
1.2) a
0.3 (0.1 to
0.7) a
0.6 (0.4 to
1.0) a
0.9 (0.7 to
1.3) a
Low
Very
low
Very
low
Very
low
83