A5V4d

Feverish illness in children
Table 5.31 GRADE profile for evaluation of diarrhoea
Number
of
studies
Diarrhoea
82
Number
of
children
Sensitivity
(95%
confidence
interval)
For detecting serious bacterial infection
1 (Craig,
2010)
1
(Berger,
1996)
15781 21 (19 to
24) a
138 55 (38 to
72) a
For detecting urinary tract infection
1
(Morris,
2007)
Specificity
(95%
confidence
interval)
74 (73 to
75) a
20 (12 to
28) a
Positive
predictive
value
(95%
confidence
interval)
6 (5 to 7) a
18 (10 to
25) a
Negative
predictive
value
(95%
confidence
interval)
92 (92 to
93) a
58 (42 to
74) a
Positive
likelihood
ratio
(95%
confidence
interval)
0.8 (0.7 to
0.9) a
0.7 (0.5 to
0.9) a
Negative
likelihood
ratio
(95%
confidence
interval)
1.1 (1.0 to
1.1) a
2.3 (1.3 to
3.9) a
98 NC b NC b NC b NC b NC b NC b Low
For detecting bacterial illness
1
(Trautne
r, 2006)
103 NC c NC c NC c NC c NC c NC c Very
low
Diarrhoea and vomiting
For detecting serious bacterial infection
1
(Nijman,
2011)
1255 6 (2 to 10) a 91 (89 to
92) a
Mild gastrointestinal symptoms
For detecting serious bacterial infection
1 (Shin,
2009)
221
15 (4 to 25)
a
89 (84 to
94) a
7 (2 to 12) a 89 (87 to
91) a
24 (7 to 41)
a
81 (76 to
87) a
0.6 (0.3 to
1.3) a
1.3 (0.6 to
3.1) a
CI confidence interval, NC non-calculable, OR odds ratio
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study.
b Text in the paper stated that diarrhoea is not predictive of urinary tract infection
c The paper reported: OR 3.93 (95% CI 1.27 to 12.19)
1.0 (1.0 to
1.1) a
1.0 (0.8 to
1.1) a
Quality
Low
Low
Very
low
Low