A5V4d

Table 5.30 GRADE profile for evaluation of non-blanching rash
Number
of
studies
Rash
Number
of
children
Sensitivity
(95%
confidence
interval)
For detecting serious bacterial infection
1
(Nijman,
2011)
Specificity
(95%
confidence
interval)
1255 3 (0 to 6) a 97 (96 to 98)
a
For detecting pneumonia, UTI or bacteraemia
1 (Craig,
2010)
Purpura
12,807 12
(10 to 14) a
For detecting bacteraemia
1 Mandl
(1997)
1
(Nademi
, 2001)
1
(Baker,
1989)
1
(Offringa
, 1992)
1 Mandl
(1997)
1
(Nielsen,
2001)
1
(Nielsen,
2001)
1
(Nielsen,
2001)
411 83
(40 to 99)
141 29
(15 to 43)
190 40
(15 to 65) a
401 13
(0 to 27) a
411 83
(54 to 100) a
208 74
(61 to 88) a
208 95
(88 to 100)
a
208 74
(61 to 88) a
82
(81 to 83) a
97
(95 to 98)
98
(95 to 100)
89
(80 to 98) a
100
(100 to 100)
a
97
(95 to 99) a
49
(42 to 57) a
78
(72 to 84) a
92
(88 to 96) a
Positive
predictive
value
(95%
confidence
interval)
12 (1 to 23)
a
5
(4 to 6) a
31
(5 to 57)
86
(67 to 100)
55
(25 to 84) a
100
(100 to 100)
a
31
(9 to 54) a
25
(17 to 33) a
50
(39 to 61) a
67
(53 to 81) a
Clinical assessment of the child with fever
Negative
predictive
value
(95%
confidence
interval)
90 (88 to
91) a
92
(92 to 93) a
99
(99 to 100)
77
(69 to 84)
82
(71 to 92) a
78
(69 to 86) a
100
(99 to 100) a
89
(83 to 96) a
99
(96 to 100) a
94
(90 to 98) a
Positive
likelihood
ratio
(95%
confidence
interval)
1.1 (0.4 to
3.1) a
0.7
(0.6 to 0.8) a
28.1
(14.5 to
54.5) a
8.9
(2.6 to 30.4)
a
3.6
(1.3 to 10.1)
a
Negative
likelihood
ratio
(95%
confidence
interval)
1.0 (1.0 to
1.0) a
1.1
(1.1 to 1.1)
a
0.2
(0.0 to 1.0)
a
0.8
(0.6 to 0.9)
a
0.7
(0.4 to 1.0)
a
NC 0.9
(0.7 to 1.0)
a
28.5
(14.4 to
56.4) a
1.5
(1.2 to 1.9) a
4.3
(3.2 to 5.8) a
9.0
(5.3 to 15.3)
a
NC Not calculable
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
0.2
(0.0 to 1.0)
a
0.5
(0.3 to 0.9)
a
0.1
(0.0 to 0.3)
a
0.3
(0.2 to 0.5)
a
Quality
Very
low
Low
Very
low
Very
low
Very
low
Very
low
Very
low
Very
low
Very
low
Very
low
81