A5V4d

Clinical assessment of the child with fever
Table 5.25 GRADE profile for evaluation of height of fever in all ages up to 5 years, including those less than 3
months
Number
of
studies
Number
of
children
Temperature ≥ 37.4°C
Sensitivity
(95%
confidence
interval)
For detecting urinary tract infection
1
(Shettiga
r, 2011)
334 100 (100 to
100) a
Temperature ≥ 37.5°C
For detecting serious bacterial infection
1 (Brent,
2011)
1716 61 (49 to
72)
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
Negative
predictive
value
(95%
confidence
interval)
Positive
likelihood
ratio
(95%
confidence
interval)
0 (0 to 0) a 8 (5 to 11) a NC 1.0 (1.0 to
1.0) a
65 (62 to
67)
For detecting malaria or bacterial meningitis
1
(Owusu-
Ofori,
2004)
608 75 (67 to
83) a
For detecting serious illness
1
(Yeboah-
Antwi,
2008)
1
(Yeboah-
Antwi,
2008)
1
(Yeboah-
Antwi,
2008)
21 (8 to 34)
a
7 (5 to 9) 2 (2 to 3) 1.7 (0.7 to
4.5)
74 (66 to
82) a
22 (8 to 35)
a
0.9 (0.8 to
1.1) a
Negative
likelihood
ratio
(95%
confidence
interval)
Quality
NC Modera
te
0.6 (0.2 to
1.6)
1.2 (0.6 to
2.4) a
685 NR/NC b NR/NC b NR/NC b NR/NC b NR/NC b NR/NC b Low
685 NR/NC c NR/NC c NR/NC c NR/NC c NR/NC c NR/NC c Low
685 NR/NC d NR/NC d NR/NC d NR/NC d NR/NC d NR/NC d Low
For detecting severe illness requiring hospitalisation
1
(YICSSG
, 2008)
1
(YICSSG
, 2008)
1
(YICSSG
, 2008)
8889 NR/NC e NR/NC e NR/NC e NR/NC e NR/NC e NR/NC e Low
8889 NR/NC f NR/NC f NR/NC f NR/NC f NR/NC f NR/NC f Low
Very
low
8889 NR/NC g NR/NC g NR/NC g NR/NC g NR/NC g NR/NC g Low
Low
73