A5V4d

Feverish illness in children
Table 5.24 GRADE profile for evaluation of height of fever in children younger than 3 months
Number
of
studies
72
Number
of
children
Temperature ≥ 38.0°C
Sensitivity
(95%
confidence
interval)
For detecting serious bacterial infection
1
(Stanley,
2005)
For detecting sepsis
1
(Weber,
2003)
5279 100 (100 to
100) a
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
Negative
predictive
value
(95%
confidence
interval)
Positive
likelihood
ratio
(95%
confidence
interval)
0 (0 to 0) a 9 (8 to 10) a NC 1.0 (1.0 to
1.0) a
Negative
likelihood
ratio
(95%
confidence
interval)
Quality
NC Very
low
3303 NR/NC b NR/NC b NR/NC b NR/NC b NR/NC b NR/NC b Low
For detecting bacterial meningitis
1
(Weber,
2003)
3303 NR/NC c NR/NC c NR/NC c NR/NC c NR/NC c NR/NC c Low
Temperature > 39.0°C
For detecting urinary tract infection
1 (Zorc,
2005)
1025 37 (27 to
47) a
Temperature ≥ 39.5°C
For detecting serious bacterial infection
1
(Zarkesh,
2011)
202 24 (10 to
37) a
81 (78 to
83) a
76 (70 to
83) a
16 (11 to
21) a
19 (8 to 30)
a
93 (91 to
95) a
81 (75 to
87) a
For detecting occult bacteraemia, urinary tract infection, or bacteraemia
1
(Gomez,
2010)
1018 26 (8 to 44)
a
Temperature ≥ 40.0°C
91 (89 to
93) a
6 (1 to 11) a 98 (97 to
99) a
2.0 (1.4 to
2.6) a
1.0 (0.5 to
1.9) a
2.8 (1.4 to
5.8) a
For detecting bacterial meningitis, bacteraemia, urinary tract infection, or salmonella enteritis
1
(Bonadio
, 1994)
1
(Stanley,
2005)
356 21 (7 to 35)
a
96 (94 to
98) a
5279 7 (5 to 10) a 99 (99 to
99) a
35 (14 to
56) a
38 (28 to
48) a
92 (89 to
95) a
91 (91 to
92) a
5.3 (2.3 to
12.3) a
6.1 (4.1 to
9.3) a
CI confidence interval, NC not calculable, NR/NC not reported/not calculable, OR odds ratio
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
b OR 3.6 (95% CI 2.6 to 5.1)
c OR 11.8 (95% CI 5.7 to 24.6)
0.8 (0.7 to
0.9) a
1.0 (0.8 to
1.2) a
0.8 (0.6 to
1.0) a
0.8 (0.7 to
1.0) a
0.9 (0.9 to
1.0) a
Moderate
Low
Very
low
Very
low
Very
low