A5V4d

Number
of
studies
Number
of
children
Sensitivity
(95%
confidence
interval)
Fever duration ≥ 72 hours
For detecting urinary tract infection
1
(Salleeh,
2010)
818 NR/NC c
Fever duration > 3 days
Specificity
(95%
confidence
interval)
NR/NC c
For detecting serious bacterial infection
1
(Factor,
2001)
669 25 (21 to
30) a
85 (81 to 89)
a
Positive
predictive
value
(95%
confidence
interval)
NR/NC c
69 (61 to
76) a
Clinical assessment of the child with fever
Negative
predictive
value
(95%
confidence
interval)
NR/NC c
47 (42 to
51) a
Positive
likelihood
ratio
(95%
confidence
interval)
NR/NC c
1.7 (1.2 to
2.3) a
CI confidence interval, NR/NC not reported/not calculable, OR odds ratio, P probability, RR risk ratio
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
b OR 1.04 (95% CI 0.35 to 3.12)
c RR 1.6 (95% 1.2 to 2.1), P = 0.002
Table 5.23 GRADE profile for comparison of duration of fever
Number of
studies
Duration of fever
Negative
likelihood
ratio
(95%
confidence
interval)
NR/NC c
0.9 (0.8 to
0.9) a
Quality
Very
low
Duration of fever Effect Quality
With serious bacterial
illness/infection (SBI) (Mean)
For detecting serious bacterial infection
Without SBI (Mean) P value
1 (Hsiao, 2006) 26.5 hours (SD 41.5) 18.6 hours (SD 21.7) P < 0.001 High
1 (Bleeker, 2007) 2.5 days (SD 2.6) 2.6 days (SD 2.3) NR High
1 (Lacour, 2001) Median 27 hours (range 2 to 140) Median 24 hours (range 2 to
140)
1 (Galetto-Lacour,
2003)
1 (Olaciregui,
2009)
Median 48 hours (range 6 to 140) Median 24 hours (range 1 to
140)
Low
P = 0.02 High
P = 0.026 High
18.62 hours (SD 35.8) 13.81 hours (SD 26) P = 0.26 Moderate
1 (Bleeker, 2001) 2.6 days (SD 2.2) 3.2 days (SD 2.8) P < 0.15 Moderate
1 (Fouzas, 2010) Median 14 hours (IQR 6 to 29) Median 14 hours (IQR 6 to
27)
For detecting meningococcal disease
1 (Nielsen, 2001) Median 21 hours (IQR/range NR) Median 24 hours (IQR/range
NR)
P = 0.49 Moderate
P not
significant
IQR interquartile range, NR not reported, P probability, SBI serious bacterial illness/infection, SD standard deviation
Low
71