A5V4d

Feverish illness in children
Table 5.22 GRADE profile for evaluation of duration of fever
Number
of
studies
70
Number
of
children
Sensitivity
(95%
confidence
interval)
Fever duration > 12 hours
For detecting serious bacterial infection
1 (Pratt,
2007)
119 44 (22 to
67) a
For detecting bacteraemia
1
(Haddon
, 1999)
534 65 (42 to
87) a
Fever duration ≥ 24 hours
For detecting urinary tract infection
1
(Newma
n, 2002)
1666 19 (13 to
25) a
For detecting bacteraemia
1
(Teach,
1997)
6619 60 (53 to
67) a
Fever duration >24 hours
For detecting serious bacterial infection
1
(Andreol
a, 2007)
408 52 (42 to
62) a
Fever duration ≥ 2 days
For detecting bacteraemia
1
(Teach,
1997)
6619 18 (12 to
23) a
Fever duration > 48 hours
For detecting serious bacterial infection
1
(Berger,
1996)
1
(Trautne
r, 2006)
138 39 (23 to
56) a
103 NR/NC b
Specificity
(95%
confidence
interval)
19 (15 to 22)
a
38 (29 to 48)
a
90 (89 to 92)
a
28 (27 to 30)
a
31 (26 to 36)
a
74 (73 to 75)
a
82 (75 to 89)
a
NR/NC b
Positive
predictive
value
(95%
confidence
interval)
2 (1 to 3) a
15 (7 to 23)
a
17 (11 to
22) a
2 (2.00 to 3)
a
18 (14 to
23) a
2 (1 to 3) a
41 (24 to
58) a
NR/NC b
Negative
predictive
value
(95%
confidence
interval)
90 (85 to
96) a
87 (77 to
97) a
91 (90 to
93) a
96 (95 to
97) a
69 (61 to
76) a
97 (96 to
97) a
81 (74 to
89) a
NR/NC b
Positive
likelihood
ratio
(95%
confidence
interval)
0.5 (0.3 to
0.9) a
1.0 (0.7 to
1.5) a
1.9 (1.3 to
2.7) a
0.8 (0.7 to
0.9) a
0.8 (0.6 to
0.9) a
0.7 (0.5 to
0.9) a
2.2 (1.2 to
3.9) a
NR/NC b
Negative
likelihood
ratio
(95%
confidence
interval)
3.0 (1.9 to
4.7) a
0.9 (0.5 to
1.8) a
0.9 (0.8 to
1.0) a
1.4 (1.2 to
1.7) a
1.5 (1.2 to
2.0) a
1.1 (1.0 to
1.2) a
0.7 (0.6 to
1.0) a
NR/NC b
Quality
Very
low
Very
low
Low
Very
low
Low
Very
low
Low
Low