A5V4d

Table 5.20 GRADE profile for evaluation of capillary refill time
Number
of
studies
Number
of
children
Sensitivity
(95%
confidence
interval)
Capillary refill time of 2 to 3 seconds
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
For detecting pneumonia, urinary tract infection and bacteraemia
1 (Craig,
2010)
12807 10 (8 to 11)
a
Capillary refill time of > 3 seconds
96 (96 to
96) a
17 (14 to
19) a
For detecting pneumonia, urinary tract infection and bacteraemia
1 (Craig,
2010)
12807 1 (1 to 2) a 100 (100 to
100) a
35 (22 to
49) a
Clinical assessment of the child with fever
Negative
predictive
value
(95%
confidence
interval)
93 (93 to
94) a
93 (92 to
93) a
Positive
likelihood
ratio
(95%
confidence
interval)
2.6 (2.1 to
3.1) a
7.0 (3.9 to
12.7) a
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
Table 5.21 GRADE profile for evaluation of reduced urine output
Number
of
studies
Number
of
children
Reduced urine output
Sensitivity
(95%
confidence
interval)
For detecting urinary tract infection
1
(Newma
n, 2002)
Poor micturition
1666 17 (11 to
23) a
For detecting serious bacterial infection
1
(Bleeker,
2001)
231 33 (26 to
40) a
Specificity
(95%
confidence
interval)
86 (85 to
88) a
79 (69 to
90) a
Positive
predictive
value (95%
confidence
interval)
Negative
predictive
value (95%
confidence
interval)
12 (8 to16) a 91 (89 to
92) a
83 (74 to
92) a
a Calculated by NCC-WCH based on results reported in the study
28 (22 to
35) a
Positive
likelihood
ratio
(95%
confidence
interval)
1.2 (0.8 to
1.8) a
1.6 (0.9 to
2.8) a
Negative
likelihood
ratio
(95%
confidence
interval)
0.9 (0.9 to
1.0) a
1.0 (1.0 to
1.0) a
Negative
likelihood
ratio
(95%
confidence
interval)
1.0 (0.9 to
1.0) a
0.8 (0.7 to
1.0) a
Quality
Low
Low
Quality
Low
Very
low
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