A5V4d

Feverish illness in children
Table 5.18 GRADE profile for evaluation of cough
Number
of
studies
Cough
68
Number
of
children
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
For detecting pneumonia, urinary tract infection, or bacteraemia
1 (Craig,
2010)
12,807 58 (55 to
61) a
For detecting urinary tract infection
1
(Newma
n, 2002)
46 (46 to 47)
a
1666 1 (0 to 2) a 98 (98 to 99)
a
For detecting meningococcal disease
1
(Nielsen,
2001)
208
15 (4 to 27)
a
63 (55 to 70)
a
Negative
predictive
value
(95%
confidence
interval)
8 (7 to 8) a 93 (93 to
94) a
4 (0 to 11) a 90 (89 to
92) a
9 (2 to 15) a 76 (69 to
83) a
Positive
likelihood
ratio
(95%
confidence
interval)
1.1 (1.0 to
1.1) a
0.4 (0.1 to
2.7) a
0.4 (0.2 to
0.9) a
NA Not applicable
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
Table 5.19 GRADE profile for evaluation of poor feeding
Number
of
studies
Poor intake
Number
of
children
Sensitivity
(95%
confidence
interval)
For detecting serious bacterial infection
1
(Bleeker,
2001)
Poor feeding
231 36 (29 to
44) a
For detecting serious disease
1
(Nademi
, 2001)
141 78 (65 to
90)
For detecting serious bacterial infection
1 (Shin,
2009)
Decreased feeding
221 27 (13 to
40) a
For detecting urinary tract infection
1
(Newma
n, 2002)
1666 37 (29 to
44) a
Specificity
(95%
confidence
interval)
74 (63 to 85)
a
Positive
predictive
value
(95%
confidence
interval)
81 (72 to
90) a
43 (33 to 52) 36 (25 to
45)
63 (56 to 70)
a
63 (60 to 65)
a
15 (7 to 23)
a
Negative
predictive
value
(95%
confidence
interval)
28 (21 to
35) a
83 (72 to
92)
78 (71 to
85) a
9 (7 to 12) a 90 (88 to
92) a
Positive
likelihood
ratio
(95%
confidence
interval)
1.4 (0.9 to
2.3) a
1.4 (1.1 to
1.7) a
0.7 (0.4 to
1.2) a
1.0 (0.8 to
1.2) a
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
Negative
likelihood
ratio
(95%
confidence
interval)
0.9 (0.9 to
1.0) a
1.0 (1.0 to
1.0) a
1.3 (1.1 to
1.6) a
Negative
likelihood
ratio
(95%
confidence
interval)
0.9 (0.7 to
1.0) a
0.5 (0.3 to
0.9) a
1.2 (0.9 to
1.4) a
1.0 (0.9 to
1.1) a
Quality
Moderate
Moderate
Very
low
Quality
Very
low
Very
low
Low
Low