A5V4d

Number
of
studies
Number
of
children
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Mild upper respiratory tract infection symptoms
For detecting serious bacterial infection
1 (Shin,
2009)
221 5 (0 to 11) a 72 (65 to 79)
a
Positive
predictive
value
(95%
confidence
interval)
Clinical assessment of the child with fever
Negative
predictive
value
(95%
confidence
interval)
4 (0 to 9) a 76 (69 to
82) a
Positive
likelihood
ratio
(95%
confidence
interval)
0.2 (0.0 to
0.7) a
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
Table 5.16 GRADE profile for evaluation of wheeze
Number
of
studies
Number
of
children
Audible wheeze
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
For detecting pneumonia, urinary tract infection, or bacteraemia
1 (Craig,
2010)
Stridor
12,807 8 (7 to 10) a 94 (93 to 94)
a
Negative
predictive
value
(95%
confidence
interval)
9 (7 to 11) a 93 (92 to
93) a
For detecting pneumonia, urinary tract infection, or bacteraemia
1 (Craig,
2010)
12,807 1 (1 to 2) a 98 (98 to 98)
a
5 (2 to 7) a 93 (92 to
93) a
Positive
likelihood
ratio
(95%
confidence
interval)
1.3 (1.1 to
1.6) a
0.6 (0.4 to
1.1) a
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
Table 5.17 GRADE profile for evaluation of chest findings/abnormal chest sounds
Number
of
studies
Number
of
children
Abnormal chest sounds
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
For detecting pneumonia, urinary tract infection, or bacteraemia
1 (Craig,
2010)
Chest findings
12,807 8 (7 to 10) a 94 (93 to 94)
a
For detecting urinary tract infection
1
(Newma
n, 2002)
Negative
predictive
value
(95%
confidence
interval)
9 (7 to 11) a 93 (92 to
93) a
1666 2 (0 to 4) 95 (94 to 96) 4 (0 to 8) 90 (89 to
92)
Positive
likelihood
ratio
(95%
confidence
interval)
1.3 (1.1 to
1.6) a
0.4 (0.1 to
1.2)
a Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
Negative
likelihood
ratio
(95%
confidence
interval)
1.3 (1.2 to
1.5) a
Negative
likelihood
ratio
(95%
confidence
interval)
1.0 (1.0 to
1.0) a
1.0 (1.0 to
1.0) a
Negative
likelihood
ratio
(95%
confidence
interval)
1.0 (1.0 to
1.0) a
1.0 (1.0 to
1.1)
Quality
Low
Quality
Moderate
Moderate
Quality
Moderate
Moderate
67