A5V4d

Feverish illness in children
Number
of
studies
Coma
64
Number
of
children
Sensitivity
(95%
confidence
interval)
For detecting bacterial meningitis
1
(Ghotbi,
2009)
1
(Offringa
, 1992)
Unrousable coma
Specificity
(95%
confidence
interval)
254 8 (0 to 24) a 100 (100 to
100) a
92 26 (8 to 44)
a
For detecting bacterial meningitis
1
(Akpede,
1992)
522 22 (5 to 40)
a
100 (100 to
100) a
94 (92 to
96) a
Positive
predictive
value
(95%
confidence
interval)
100 (100 to
100) a
100 (100 to
100) a
15 (3 to 27)
a
NC Not calculable
a Calculated by the NCC-WCH based on data reported in the study
Table 5.11 GRADE profile for evaluation of restlessness
Number
of
studies
Restlessness
Number
of
children
Sensitivity
(95%
confidence
interval)
For detecting serious illness
1
(Nademi
, 2001)
141 76 (62 to
88)
Specificity
(95%
confidence
interval)
43 (33 to
52)
a Calculated by the NCC based on data reported in the study
Table 5.12 GRADE profile for evaluation of tachypnoea
Number
of
studies
Tachypnea
Number
of
children
For detecting pneumonia
1
(Taylor,
1995)
Sensitivity
(95%
confidence
interval)
572 74 (70 to
77)
Specificity
(95%
confidence
interval)
77 (77 to
80)
Positive
predictive
value
(95%
confidence
interval)
35 (25 to
45)
Positive
predictive
value
(95%
confidence
interval)
20 (17 to
23)
Negative
predictive
value
(95%
confidence
interval)
96 (93 to
98) a
80 (72 to
89) a
97 (95 to
98) a
Negative
predictive
value
(95%
confidence
interval)
81 (70 to
91)
Negative
predictive
value
(95%
confidence
interval)
97 (96 to
99)
Positive
likelihood
ratio
(95%
confidence
interval)
Negative
likelihood
ratio
(95%
confidence
interval)
NC 0.9 (0.8 to
1.1) a
NC 0.7 (0.6 to
0.9) a
3.9 (1.7 to
9.1) a
Positive
likelihood
ratio
(95%
confidence
interval)
1.3 (1.0 to
1.7) a
Positive
likelihood
ratio
(95%
confidence
interval)
3.2 (2.5 to
4.0) a
0.8 (0.7 to
1.0) a
Negative
likelihood
ratio
(95%
confidence
interval)
0.6 (0.3 to
1.0) a
Negative
likelihood
ratio
(95%
confidence
interval)
0.3 (0.2 to
0.6) a
Quality
Modera
te
Very
low
Low
Quality
Very
low
Quality
Low