A5V4d

Clinical assessment of the child with fever
NC Not calculable
a Confidence intervals calculated by a member of the technical team at the NCC-WCH based on results reported in the study
b Calculated by a member of the technical team at the NCC-WCH based on results reported in the study
Table 5.7 GRADE profile for evaluation of decreased activity
Number
of
studies
Number
of
children
Decreased activity
Sensitivity
(95%
confidence
interval)
For detecting urinary tract infection
1
(Newma
n, 2002)
1666 17 (12 to
23) a
Specificity
(95%
confidence
interval)
82 (80 to
84) a
Decreased activity level during examination
For detecting bacteraemia
1 (Crain,
1982)
Positive
predictive
value
(95%
confidence
interval)
Negative
predictive
value
(95%
confidence
interval)
9 (6 to 12) a 90 (89 to
92) a
Positive
likelihood
ratio
(95%
confidence
interval)
0.9 (0.7 to
1.3) a
Negative
likelihood
ratio
(95%
confidence
interval)
1.0 (0.9 to
1.1) a
Quality
175 NC NC NC NC NC NC Modera
te
Looking around the room (moderately impaired)
For detecting serious bacterial infection
1
(Berger,
1996)
138 21 (7 to 35)
a
69 (60 to
78) a
Looking around the room (severely impaired)
For detecting serious bacterial infection
1
(Berger,
1996)
138 30 (15 to
46) a
92 (87 to
97) a
18 (6 to 30)
a
56 (33 to
79) a
Moving arms and legs spontaneously (moderately impaired)
For detecting serious bacterial infection
1
(Berger,
1996)
138 27 (12 to
42) a
78 (70 to
86) a
28 (13 to
44) a
Moving arms and legs spontaneously (severely impaired)
For detecting serious bacterial infection
1
(Berger,
1996)
138 24 (10 to
39) a
96 (93 to
100) a
Reaching for objects (moderately impaired)
For detecting serious bacterial infection
1
(Berger,
1996)
138 15 (3 to 27)
a
77 (69 to
85) a
67 (40 to
93) a
17 (3 to 31)
a
73 (64 to
82) a
81 (73 to
88) a
77 (69 to
85) a
80 (73 to
87) a
74 (66 to
83) a
0.7 (0.3 to
1.4) a
3.9 (1.7 to
9.0) a
1.2 (0.6 to
2.4) a
6.4 (2.0 to
19.8) a
0.7 (0.3 to
1.6) a
1.1 (0.9 to
1.4) a
0.8 (0.6 to
1.0) a
0.9 (0.7 to
1.2) a
0.8 (0.6 to
1.0) a
1.1 (0.9 to
1.3) a
Low
Low
Low
Low
Low
Low
61