A5V4d

Feverish illness in children
Table 9.9 GRADE findings for paracetamol and ibuprofen combined vs. paracetamol and ibuprofen alternating
Number of studies Number of children Effect Quality
Discomfort at 1 to 2 hours
No data
Discomfort at > 2 to 5 hours
No data
Discomfort at > 5 to 24 hours
No data
Discomfort > 24 hours
No data
Mean change temperature at 1 to 2 hours
No data
228
Intervention Control Relative
(95% confidence
interval)
Mean change in temperature at > 2 to 5 hours
No data
Mean change in temperature at > 5 to 24 hours
No data
Mean change in temperature at > 24 hours
No data
Mean temperature at 1 to 2 hours
1 hour
1 (Paul et al., 2010) 37.4°C (SD
0.5), n = 20 a
2 hours
1 (Paul et al., 2010) 37.0°C (SD
0.5), n = 20 a
Mean temperature at > 2 to 5 hours
3 hours
1 (Paul et al., 2010) 36.9°C (SD
0.4), n = 20 a
4 hours
1 (Paul et al., 2010) 36.9°C (SD
0.3), n = 20 a
5 hours
1 (Paul et al., 2010) 36.9°C (SD
0.5), n = 20 a
37.6°C (SD
0.4), n = 20 b
37.2°C (SD
0.3), n = 20 b
36.9°C (SD
0.4), n = 20 b
36.9°C (SD
0.3), n = 20 b
36.8°C (SD
0.3), n = 20 b
SMD -0.43 (-1.06 to
+0.19)
SMD -0.48 (-1.10 to
+0.15)
SMD 0.00 (-0.62 to
+0.62)
SMD 0.00 (-0.62 to
+0.62)
SMD 0.24 (-0.38 to
+0.86)
Absolute
(95%
confidence
interval)
- Low
- Low
- Low
- Low
- Low