A5V4d

Table 9.8 GRADE findings for ibuprofen vs. paracetamol and ibuprofen alternating
Antipyretic interventions
Number of studies Number of children Effect Quality
Discomfort at 1 to 2 hours
No data
Discomfort at > 2 to 5 hours
No data
Discomfort at > 5 to 24 hours
Day 1
NCCPC score
1 (Sarrell et al.,
2006)
Discomfort at > 24 hours
Day 2
NCCPC score
1 (Sarrell et al.,
2006)
Day 3
NCCPC score
1 (Sarrell et al.,
2006)
Intervention Control Relative
(95% confidence
interval)
9.26 (SD 2.49),
n = 155 a
5.09 (SD 2.78),
n = 155 a
4.18 (SD 2.74),
n = 155 a
Mean change temperature at 1 to 2 hours
No data
Mean change in temperature at > 2 to 5 hours
No data
Mean change in temperature at > 5 to 24 hours
No data
Mean change in temperature at > 24 hours
No data
Mean temperature at 1 to 2 hours
1 hour
1 (Paul et al., 2010) 37.6°C (SD
0.4),
n = 20 c
2 hours
1 (Paul et al., 2010) 37.2°C (SD
0.3),
n = 20 c
11.48 (SD
2.58), n = 155 b
8.83 (SD 2.67),
n = 155 b
7.96 (SD 2.71),
n = 155 b
37.6°C (SD
0.5),
n = 20 c
37.1°C (SD
0.4),
n = 20 d
SMD -0.87 (-1.11 to
-0.64)
SMD -1.37 (-1.62 to
-1.12)
SMD -1.38 (-1.63 to
-1.14)
SMD 0.00 (-0.62 to
+0.62)
SMD 0.28 (-0.35 to
+0.90)
Absolute
(95%
confidence
interval)
-
- High
- High
- Very low
- Very low
225