A5V4d

Feverish illness in children
Number of studies Number of children Effect Quality
Afebrile at > 5 to 24 hours
6 hours
1 (Hay et al., 2009) 47 of 52 a
1 (Paul et al., 2010) 19 of 20 e
8 hours
1 (Hay et al., 2009) 45 of 52 a
12 hours
224
Combined Mono Relative
(95% confidence
interval)
37 of 52 b
10 of 20 f
46 of 52 b
Absolute
(95%
confidence
interval)
RR 1.27 (1.05 to 1.54) - Moder
ate
RR 1.90 (1.21 to 2.98) - Low
RR 0.98 (0.85 to 1.13) - Moder
ate
1 (Hay et al., 2009) 49 of 52 47 of 52 RR 1.04 (0.93 to 1.17) - Moder
ate
Afebrile at > 24 hours
24 hours
1 (Hay et al., 2009) 47 of 52 a
Time without fever
4 hours
45 of 52 b
1 (Hay et al., 2009) 171.1 (40.8) 156.0 (57.6) adjusted mean
difference 16.2 (-7.0 to
39.4), P = 0.2
24 hours
1 (Hay et al., 2009) 1217.4 (237.6) 1055.2 (329.7) adjusted mean
difference 2.5 (0.6 to
4.4), P = 0.008
Adverse events
Diarrhoea
1 (Hay et al., 2009) 12 of 52 9 of 52
Vomiting
RR 1.04 (0.91 to 1.20) - Moder
ate
- Moder
ate
- Moder
ate
RR 0.75 (0.35 to 1.63) - Very
low
1 (Hay et al., 2009) 2 of 52 3 of 52 RR 1.50 (0.26 to 8.61) - Very
low
NC non-calculable, NR not reported, OP odds ratio, RR relative risk, SD standard deviation, SMD standard mean difference
a Hay – 15 mg/kg paracetamol + 10 mg/kg ibuprofen
b 10 mg/kg ibuprofen
c 15 mg/kg + 5 mg/kg
d 5 mg/kg ibuprofen
e 10 mg/kg Ibuprofen and 15 mg/kg acetaminophen single dose
f 10 mg/kg Ibuprofen single dose